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Tbio
PACS2
Phosphofurin acidic cluster sorting protein 2

Protein Summary
Description
Multifunctional sorting protein that controls the endoplasmic reticulum (ER)-mitochondria communication, including the apposition of mitochondria with the ER and ER homeostasis. In addition, in response to apoptotic inducer, translocates BIB to mitochondria, which initiates a sequence of events including the formation of mitochondrial truncated BID, the release of cytochrome c, the activation of caspase-3 thereby causing cell death. May also be involved in ion channel trafficking, directing acidic cluster-containing ion channels to distinct subcellular compartments.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000325438
  • ENSP00000321834
  • ENSG00000179364
  • ENST00000430725
  • ENSP00000393524
  • ENST00000447393
  • ENSP00000393559

Symbol
  • KIAA0602
  • PACS1L
  • EIEE66
  • PACS-2
  • PACS1L
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.89
kinase perturbation
0.88
disease perturbation
0.87
virus perturbation
0.79
tissue sample
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.93   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 114.93   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (82)
1 – 10 of 82
LRRC46
Tdark
Novelty: 1.159245
p_int: 0.99999999
p_ni: 3e-9
p_wrong: 7e-9
Score: 0.808
Data Source: BioPlex,STRINGDB
WDR37
Tbio
Novelty: 0.1677975
p_int: 0.999999484
p_ni: 3.75e-7
p_wrong: 1.41e-7
Score: 0.904
Data Source: BioPlex,STRINGDB
LEAP2
Tbio
Novelty: 0.01484908
p_int: 0.99994753
p_ni: 0.00005035
p_wrong: 0.00000212
Data Source: BioPlex
BCAP31
Tbio
Novelty: 0.01363316
Score: 0.78
Data Source: STRINGDB
PKD2
Tchem
Family: IC
Novelty: 0.00305329
Score: 0.769
Data Source: STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00278138
Score: 0.752
Data Source: STRINGDB
MFN2
Tbio
Novelty: 0.00137876
Score: 0.698
Data Source: STRINGDB
ITPR3
Tchem
Family: IC
Novelty: 0.00154917
Score: 0.686
Data Source: STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00111834
Score: 0.68
Data Source: STRINGDB
HSPA9
Tbio
Novelty: 0.00235171
Score: 0.676
Data Source: STRINGDB
Publication Statistics
PubMed Score  114.93

PubMed score by year
PubTator Score  48.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer