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Tchem
CASP14
Caspase-14

Protein Summary
Description
Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substrate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736). This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000427043
  • ENSP00000393417
  • ENSG00000105141

Symbol
  • ARCI12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.85
cell type or tissue
0.82
biological process
0.6
tissue sample
0.55
biological term
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 448   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.32   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 448   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 1
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (1)
1 – 1 of 1
CHEMBL567893
chemical structure image
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
caspase 14
718049
Mouse
MGI:1335092
12365
Rat
RGD:1311781
299587
Dog
caspase 14
VGNC:38732
610460
Horse
caspase 14
VGNC:16066
100062886
Species
Name
OMA
EggNOG
Inparanoid
Macaque
caspase 14
Mouse
Rat
Dog
caspase 14
Horse
caspase 14
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P31944-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (8)
Developmental Biology (R-HSA-1266738)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Developmental Biology
Reactome
Formation of the cornified envelope
Reactome
Keratinization
Name
Explore in Pharos
Explore in Source
Developmental Biology
Formation of the cornified envelope
Keratinization
Protein-Protein Interactions (91)
1 – 10 of 91
ZIC1
Tbio
Family: TF
Novelty: 0.00491601
p_int: 0.995251019
p_ni: 0.004748981
Score: 0.186
Data Source: BioPlex,STRINGDB
FTH1
Tbio
Novelty: 0.000863
p_int: 0.983034147
p_ni: 0.016965852
p_wrong: 1e-9
Score: 0.183
Data Source: BioPlex,STRINGDB
TBC1D22B
Tbio
Novelty: 0.49852962
p_int: 0.903755044
p_ni: 0.096244956
Data Source: BioPlex
FCF1
Tdark
Novelty: 0.04202976
p_int: 0.805323881
p_ni: 0.194676119
Score: 0.16
Data Source: BioPlex,STRINGDB
NDUFS5
Tclin
Family: Enzyme
Novelty: 0.13274675
p_int: 0.781873758
p_ni: 0.218126242
Data Source: BioPlex
EHBP1
Tbio
Novelty: 0.0656858
p_int: 0.768749844
p_ni: 0.231250156
Data Source: BioPlex
FLG
Tbio
Novelty: 0.00072986
Score: 0.972
Data Source: Reactome,STRINGDB
LOR
Tbio
Novelty: 0.0033781
Score: 0.966
Data Source: STRINGDB
IVL
Tbio
Novelty: 0.00147892
Score: 0.955
Data Source: STRINGDB
CDSN
Tbio
Novelty: 0.01118491
Score: 0.946
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  88.32

PubMed score by year
PubTator Score  65.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer