Protein Classes
Protein Summary
Receptor for thromboxane A2 (TXA2), a potent stimulator of platelet aggregation. The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system. In the kidney, the binding of TXA2 to glomerular TP receptors causes intense vasoconstriction. Activates phospholipase C. Isoform 1 activates adenylyl cyclase. Isoform 2 inhibits adenylyl cyclase. This gene encodes a member of the G protein-coupled receptor family. The protein interacts with thromboxane A2 to induce platelet aggregation and regulate hemostasis. A mutation in this gene results in a bleeding disorder. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
- ENST00000375190
- ENSP00000364336
- ENSG00000006638
- ENST00000411851
- ENSP00000393333
- TXA2-R
- BDPLT13
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
ligand (chemical) | 0.96 | ||
histone modification site profile | 0.81 | ||
kinase | 0.72 | ||
tissue sample | 0.69 | ||
biological term | 0.67 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.04 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 170 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 141.04 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 170 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 319
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Approved Drugs (4)
1 – 4 of 4
Active Ligands (319)
1 – 10 of 319
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id | Ligand | Method | Resolution (Ã…) | M.W. (kDa) | Pub Year | Title |
---|
PDB Structure Id | M.W. | Resolution | Pub Year |
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Pathways (20)
Reactome (13)
KEGG (3)
PathwayCommons (1)
WikiPathways (3)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Class A/1 (Rhodopsin-like receptors) | ||||
Reactome | Eicosanoid ligand-binding receptors | ||||
Reactome | G alpha (12/13) signalling events | ||||
Reactome | G alpha (q) signalling events | ||||
Reactome | GPCR downstream signalling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Class A/1 (Rhodopsin-like receptors) | ||||
Eicosanoid ligand-binding receptors | ||||
G alpha (12/13) signalling events | ||||
G alpha (q) signalling events | ||||
GPCR downstream signalling | ||||
Gene Ontology Terms (20)
Functions (2)
Components (4)
Processes (14)
Items per page:
10
1 – 2 of 2
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Protein-Protein Interactions (221)
1 – 10 of 221
TGM2
Family: Enzyme
Novelty: 0.00048324
Score: 0.986
Data Source: STRINGDB
GNAQ
Novelty: 0.00176666
Score: 0.968
Data Source: Reactome,STRINGDB
LTB4R
Family: GPCR
Novelty: 0.00174481
Score: 0.957
Data Source: STRINGDB
GNA13
Novelty: 0.05970556
Score: 0.955
Data Source: Reactome,STRINGDB
ADRA1B
Family: GPCR
Novelty: 0.00098873
Score: 0.953
Data Source: STRINGDB
ARRB2
Novelty: 0.00180049
Score: 0.952
Data Source: STRINGDB
GNAI2
Novelty: 0.04542644
Score: 0.952
Data Source: STRINGDB
GNB1
Novelty: 0.04716243
Score: 0.95
Data Source: Reactome,STRINGDB
GNG2
Novelty: 0.08273543
Score: 0.949
Data Source: Reactome,STRINGDB
GRK5
Family: Kinase
Novelty: 0.01219315
Score: 0.948
Data Source: STRINGDB
Publication Statistics
PubMed Score 141.04
PubMed score by year
PubTator Score 205.93
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Sequence
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGL
1-70
VLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSR
70-140
PAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGL
140-210
SFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAG
210-280
QLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
280-343
MWPNGSSLGPCFRPTNITLEERRLIASPWFAASFCVVGLASNLLALSVLAGARQGGSHTRSSFLTFLCGLVLTDFLGLLVTGTIVVSQHAALFEWHAVDPGCRLCRFMGVVMIFFGLSPLLLGAAMASERYLGITRPFSRPAVASQRRAWATVGLVWAAALALGLLPLLGVGRYTVQYPGSWCFLTLGAESGDVAFGLLFSMLGGLSVGLSFLLNTVSVATLCHVYHGQEAAQQRPRDSEVEMMAQLLGIMVVASVCWLPLLVFIAQTVLRNPPAMSPAGQLSRTTEKELLIYLRVATWNQILDPWVYILFRRAVLRRLQPRLSTRPRSLSLQPQLTQRSGLQ
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