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Tbio
EPS15L1
Epidermal growth factor receptor substrate 15-like 1

Protein Summary
Description
Seems to be a constitutive component of clathrin-coated pits that is required for receptor-mediated endocytosis. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000248070
  • ENSP00000248070
  • ENSG00000127527
  • ENST00000455140
  • ENSP00000393313
  • ENST00000535753
  • ENSP00000440103
  • ENST00000597937
  • ENSP00000472267
  • ENST00000602022
  • ENSP00000471981

Symbol
  • EPS15R
  • EPS15R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.96
kinase perturbation
0.95
interacting protein
0.91
phenotype
0.85
ligand (protein) perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.19   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 13.19   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
5
5
6
95.5
leukocyte count
3
3
3
93.4
2
2
0
1.1
87.5
myeloid white cell count
1
1
1
84.4
lymphocyte percentage of leukocytes
2
3
3
75.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
6
95.5
leukocyte count
3
93.4
0
1.1
87.5
myeloid white cell count
1
84.4
lymphocyte percentage of leukocytes
3
75.2
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor pathway substrate 15 like 1
VGNC:10387
455810
Macaque
epidermal growth factor receptor pathway substrate 15 like 1
719502
Mouse
MGI:104582
13859
Rat
RGD:1565708
361120
Dog
epidermal growth factor receptor pathway substrate 15 like 1
VGNC:40426
484849
Species
Name
OMA
EggNOG
Inparanoid
Chimp
epidermal growth factor receptor pathway substrate 15 like 1
Macaque
epidermal growth factor receptor pathway substrate 15 like 1
Mouse
Rat
Dog
epidermal growth factor receptor pathway substrate 15 like 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9UBC2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Cargo recognition for clathrin-mediated endocytosis (R-HSA-8856825)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cargo recognition for clathrin-mediated endocytosis
Reactome
Clathrin-mediated endocytosis
Reactome
EGFR downregulation
Reactome
Membrane Trafficking
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Cargo recognition for clathrin-mediated endocytosis
Clathrin-mediated endocytosis
EGFR downregulation
Membrane Trafficking
Signal Transduction
Gene Ontology Terms (10)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (191)
1 – 10 of 191
ITSN2
Tbio
Novelty: 0.03036854
p_int: 0.999999999
p_ni: 1e-9
Score: 0.978
Data Source: BioPlex,STRINGDB
FCHO2
Tbio
Novelty: 0.12302279
p_int: 0.999999995
p_ni: 5e-9
Score: 0.979
Data Source: BioPlex,STRINGDB
ITSN1
Tbio
Novelty: 0.01327346
p_int: 0.999999941
p_ni: 5.9e-8
Score: 0.978
Data Source: BioPlex,STRINGDB
STON2
Tbio
Novelty: 0.02098671
p_int: 0.999999865
p_ni: 1.35e-7
Score: 0.983
Data Source: BioPlex,STRINGDB
EPS15
Tbio
Novelty: 0.00451447
p_int: 0.999999787
p_ni: 2.13e-7
Score: 0.931
Data Source: BioPlex,STRINGDB
AP1B1
Tbio
Novelty: 0.03370208
p_int: 0.999996027
p_ni: 0.000003973
Score: 0.655
Data Source: BioPlex,STRINGDB
SPC25
Tbio
Novelty: 0.26354244
p_int: 0.999991926
p_ni: 0.000008074
Score: 0.221
Data Source: BioPlex,STRINGDB
AP2A2
Tbio
Novelty: 0.08851191
p_int: 0.999988719
p_ni: 0.000011282
Score: 0.965
Data Source: BioPlex,STRINGDB
AP2M1
Tbio
Novelty: 0.00769368
p_int: 0.99994985
p_ni: 0.00005015
Score: 0.968
Data Source: BioPlex,STRINGDB
SYCE1
Tbio
Novelty: 0.05038876
p_int: 0.999948913
p_ni: 0.000051087
Data Source: BioPlex
Publication Statistics
PubMed Score  13.19

PubMed score by year
PubTator Score  11.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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