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Tclin
FGFR1
Fibroblast growth factor receptor 1

Protein Summary
Description
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000326324
  • ENSP00000327229
  • ENSG00000077782
  • ENST00000335922
  • ENSP00000337247
  • ENST00000356207
  • ENSP00000348537
  • ENST00000397091
  • ENSP00000380280
  • ENST00000397108
  • ENSP00000380297
  • ENST00000397113
  • ENSP00000380302
  • ENST00000425967
  • ENSP00000393312
  • ENST00000447712
  • ENSP00000400162
  • ENST00000484370
  • ENSP00000433163
  • ENST00000532791
  • ENSP00000432972

Symbol
  • BFGFR
  • CEK
  • FGFBR
  • FLG
  • FLT2
  • HBGFR
  • CEK
  • FLG
  • HH2
  • OGD
  • ECCL
  • FLT2
  • KAL2
  • BFGFR
  • CD331
  • FGFBR
  • FLT-2
  • HBGFR
  • N-SAM
  • FGFR-1
  • HRTFDS
  • bFGF-R-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
1
protein domain
1
kinase
0.96
transcription factor perturbation
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1711.04   (req: < 5)
Gene RIFs: 399   (req: <= 3)
Antibodies: 2216   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1711.04   (req: >= 5)
Gene RIFs: 399   (req: > 3)
Antibodies: 2216   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 72
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 941
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 9
Active Ligands (941)
1 – 10 of 941
CHEMBL388978
chemical structure image
CHEMBL522892
chemical structure image
CHEMBL3975634
chemical structure image
CHEMBL495727
chemical structure image
CHEMBL1784637
chemical structure image
CHEMBL3984039,CHEMBL3962736
chemical structure image
CHEMBL1822792
chemical structure image
CHEMBL2086760
chemical structure image
CHEMBL3907195,CHEMBL3944340
chemical structure image
CHEMBL3931421,CHEMBL3955800
chemical structure image
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
94.2
waist-hip ratio
2
2
2
84.7
testosterone measurement
2
2
2
74.5
2
2
0
1.1
64.8
electrocardiography
1
1
13
32.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
94.2
waist-hip ratio
2
84.7
testosterone measurement
2
74.5
0
1.1
64.8
electrocardiography
13
32.9
Protein Data Bank (54)
1 – 5 of 54
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (136)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 48
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Axon guidance
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Developmental Biology
Disease
Gene Ontology Terms (81)
Items per page:
10
1 – 10 of 13
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (319)
1 – 10 of 319
FGFR2
Tclin
Family: Kinase
Novelty: 0.00066613
p_int: 0.999999818
p_ni: 1.78e-7
p_wrong: 4e-9
Score: 0.385
Data Source: BioPlex,STRINGDB
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.99969721
p_ni: 0.00030279
Data Source: BioPlex
FAM8A1
Tbio
Novelty: 0.08206001
p_int: 0.98139968
p_ni: 0.018599832
p_wrong: 4.87e-7
Score: 0.168
Data Source: BioPlex,STRINGDB
TMEM30B
Tbio
Novelty: 0.26735006
p_int: 0.959517806
p_ni: 0.040482093
p_wrong: 1.01e-7
Data Source: BioPlex
LRRN2
Tdark
Novelty: 0.22583761
p_int: 0.945484985
p_ni: 0.054513877
p_wrong: 0.000001138
Score: 0.24
Data Source: BioPlex,STRINGDB
LITAF
Tbio
Family: TF
Novelty: 0.0097203
p_int: 0.935049573
p_ni: 0.064947665
p_wrong: 0.000002762
Data Source: BioPlex
C16orf58
Tdark
Novelty: 0.34461652
p_int: 0.931444672
p_ni: 0.068555322
p_wrong: 6e-9
Data Source: BioPlex
CD44
Tbio
Novelty: 0.00011321
p_int: 0.926843059
p_ni: 0.073156925
p_wrong: 1.7e-8
Score: 0.588
Data Source: BioPlex,STRINGDB
ZDHHC11
Tdark
Family: Enzyme
Novelty: 0.35249931
p_int: 0.919195182
p_ni: 0.078284552
p_wrong: 0.002520266
Data Source: BioPlex
GINM1
Tdark
Novelty: 1.0701107
p_int: 0.914191125
p_ni: 0.085753725
p_wrong: 0.00005515
Score: 0.153
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1711.04

PubMed score by year
PubTator Score  1214.91

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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