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Tbio
DCAF1
DDB1- and CUL4-associated factor 1

Protein Classes
Protein Summary
Description
Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase regulation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex, named CUL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins: recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed:23063525). The CUL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development: DCAF1 is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335891
  • ENSP00000338857
  • ENSG00000145041
  • ENST00000423656
  • ENSP00000393183
  • ENST00000504652
  • ENSP00000421724

Symbol
  • KIAA0800
  • RIP
  • VPRBP
  • RIP
  • VPRBP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.78   (req: < 5)
Gene RIFs: 39   (req: <= 3)
Antibodies: 110   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 68.78   (req: >= 5)
Gene RIFs: 39   (req: > 3)
Antibodies: 110   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
2
3
79.8
mathematical ability
1
1
1
73.5
1
1
0
1.1
48.1
intelligence
1
1
1
15.8
1
1
1
15.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
3
79.8
mathematical ability
1
73.5
0
1.1
48.1
intelligence
1
15.8
1
15.8
Protein Data Bank (7)
1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (20)
Items per page:
1 – 1 of 1
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Human immunodeficiency virus 1 infection
Name
Explore in Pharos
Explore in Source
Human immunodeficiency virus 1 infection
Protein-Protein Interactions (363)
1 – 10 of 363
RPL23A
Tbio
Novelty: 0.02951947
p_int: 0.99997363
p_ni: 0.00002637
Data Source: BioPlex
LLGL2
Tbio
Novelty: 0.07084531
p_int: 0.999951315
p_ni: 0.000048685
Score: 0.544
Data Source: BioPlex,STRINGDB
RPL18
Tbio
Novelty: 0.01765545
p_int: 0.998738775
p_ni: 0.001261225
Data Source: BioPlex
HPSE2
Tbio
Family: Enzyme
Novelty: 0.00583615
p_int: 0.998460554
p_ni: 0.001539446
Data Source: BioPlex
RPL15
Tbio
Novelty: 0.02466708
p_int: 0.997490652
p_ni: 0.002509348
Data Source: BioPlex
RPL7A
Tbio
Novelty: 0.01674027
p_int: 0.997230131
p_ni: 0.002769869
Data Source: BioPlex
FGFRL1
Tbio
Novelty: 0.02178846
p_int: 0.994806249
p_ni: 0.005193748
p_wrong: 3e-9
Data Source: BioPlex
TCEANC2
Tdark
Novelty: 0.40325323
p_int: 0.993563103
p_ni: 0.006436897
Data Source: BioPlex
AURKAIP1
Tchem
Family: Enzyme
Novelty: 0.19241693
p_int: 0.99212492
p_ni: 0.00787508
Data Source: BioPlex
COPS8
Tbio
Novelty: 0.0408885
p_int: 0.986312398
p_ni: 0.013687602
Score: 0.659
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  68.78

PubMed score by year
PubTator Score  47.21

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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