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Tclin
GABRA1
Gamma-aminobutyric acid receptor subunit alpha-1

Protein Classes
Protein Summary
Description
Component of the heteropentameric receptor for GABA, the major inhibitory neurotransmitter in the vertebrate brain. Functions also as histamine receptor and mediates cellular responses to histamine. Functions as receptor for diazepines and various anesthetics, such as pentobarbital; these are bound at a separate allosteric effector binding site. Functions as ligand-gated chloride channel (By similarity). This gene encodes a gamma-aminobutyric acid (GABA) receptor. GABA is the major inhibitory neurotransmitter in the mammalian brain where it acts at GABA-A receptors, which are ligand-gated chloride channels. Chloride conductance of these channels can be modulated by agents such as benzodiazepines that bind to the GABA-A receptor. GABA-A receptors are pentameric, consisting of proteins from several subunit classes: alpha, beta, gamma, delta and rho. Mutations in this gene cause juvenile myoclonic epilepsy and childhood absence epilepsy type 4. Multiple transcript variants encoding the sa ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000023897
  • ENSP00000023897
  • ENSG00000022355
  • ENST00000393943
  • ENSP00000377517
  • ENST00000428797
  • ENSP00000393097
  • ENST00000437025
  • ENSP00000415441
  • ENST00000635880
  • ENSP00000489738
  • ENST00000636573
  • ENSP00000490320
  • ENST00000637827
  • ENSP00000490804
  • ENST00000638112
  • ENSP00000489839

Symbol
  • EJM
  • ECA4
  • EJM5
  • EIEE19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
ligand (chemical)
0.97
chemical
0.94
protein domain
0.92
molecular function
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.73   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 442   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 95.73   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 442   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 16
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 70
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 49
Approved Drugs (49)
1 – 10 of 49
topiramate
chemical structure image
triazolam
chemical structure image
diazepam
chemical structure image
halothane
chemical structure image
flumazenil
chemical structure image
midazolam
chemical structure image
isoflurane
chemical structure image
zopiclone
chemical structure image
zolpidem
chemical structure image
desflurane
chemical structure image
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
GABA receptor activation (R-HSA-977443)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
GABA receptor activation
Reactome
Neuronal System
Reactome
Neurotransmitter receptors and postsynaptic signal transmission
Reactome
Signal Transduction
Reactome
Signaling by ERBB4
Name
Explore in Pharos
Explore in Source
GABA receptor activation
Neuronal System
Neurotransmitter receptors and postsynaptic signal transmission
Signal Transduction
Signaling by ERBB4
Gene Ontology Terms (29)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (195)
1 – 10 of 195
GABRG2
Tclin
Family: IC
Novelty: 0.00819163
Score: 0.991
Data Source: Reactome,STRINGDB
GABRB2
Tclin
Family: IC
Novelty: 0.01954146
Score: 0.988
Data Source: Reactome,STRINGDB
GABRB3
Tclin
Family: IC
Novelty: 0.00485997
Score: 0.979
Data Source: Reactome,STRINGDB
GABRB1
Tclin
Family: IC
Novelty: 0.02895574
Score: 0.978
Data Source: Reactome,STRINGDB
GPHN
Tbio
Novelty: 0.0020752
Score: 0.961
Data Source: STRINGDB
GABRA6
Tclin
Family: IC
Novelty: 0.02894664
Score: 0.954
Data Source: STRINGDB
GABRA4
Tclin
Family: IC
Novelty: 0.03089903
Score: 0.947
Data Source: STRINGDB
GABRA5
Tclin
Family: IC
Novelty: 0.01499706
Score: 0.939
Data Source: STRINGDB
GABRQ
Tclin
Family: IC
Novelty: 0.12221217
Score: 0.939
Data Source: Reactome,STRINGDB
DNM1
Tbio
Novelty: 0.00319082
Score: 0.932
Data Source: STRINGDB
Publication Statistics
PubMed Score  95.73

PubMed score by year
PubTator Score  81.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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