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Tbio
IGF2
Insulin-like growth factor II

Protein Summary
Description
The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation (By similarity). In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver (Probable). Acts as a ligand for integrin which is required for IGF2 signaling (PubMed:28873464). Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3. This gene encodes a member of the insulin family of polypeptide growth factors, which are involved in develo ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381389
  • ENSP00000370796
  • ENSG00000167244
  • ENST00000381392
  • ENSP00000370799
  • ENST00000381395
  • ENSP00000370802
  • ENST00000381406
  • ENSP00000370813
  • ENST00000416167
  • ENSP00000414497
  • ENST00000418738
  • ENSP00000402047
  • ENST00000434045
  • ENSP00000391826
  • ENST00000641326
  • ENSP00000493122

Symbol
  • GRDF
  • IGF-II
  • PP9974
  • C11orf43
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
gene perturbation
0.96
PubMedID
0.93
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4721.83   (req: < 5)
Gene RIFs: 492   (req: <= 3)
Antibodies: 544   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4721.83   (req: >= 5)
Gene RIFs: 492   (req: > 3)
Antibodies: 544   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
92
birth weight
2
2
2
89.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
92
birth weight
2
89.5
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (53)
Hemostasis (R-HSA-109582)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Hemostasis
Reactome
IGF1R signaling cascade
Reactome
IRS-related events triggered by IGF1R
Reactome
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Reactome
Metabolism of RNA
Name
Explore in Pharos
Explore in Source
Hemostasis
IGF1R signaling cascade
IRS-related events triggered by IGF1R
Insulin-like Growth Factor-2 mRNA Binding Proteins (IGF2BPs/IMPs/VICKZs) bind RNA
Metabolism of RNA
Gene Ontology Terms (43)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
AgBase
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (346)
1 – 10 of 346
IGFBP2
Tchem
Novelty: 0.00083618
p_int: 0.999998734
p_ni: 0.000001231
p_wrong: 3.5e-8
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
UBAC1
Tbio
Novelty: 0.00122518
p_int: 0.999996623
p_ni: 0.000003377
Data Source: BioPlex
ATXN3
Tbio
Novelty: 0.00201109
p_int: 0.999996585
p_ni: 0.000002867
p_wrong: 5.48e-7
Data Source: BioPlex
RNF123
Tbio
Family: Enzyme
Novelty: 0.01872044
p_int: 0.999967108
p_ni: 0.000032892
Data Source: BioPlex
CALU
Tbio
Novelty: 0.01285123
p_int: 0.999758178
p_ni: 0.000241823
Data Source: BioPlex
IGFBP5
Tchem
Novelty: 0.0025185
p_int: 0.999717518
p_ni: 2.07e-7
p_wrong: 0.000282275
Score: 0.995
Data Source: BioPlex,Reactome,STRINGDB
POTEF
Tbio
Novelty: 0.00191599
p_int: 0.99934058
p_ni: 0.00065942
Score: 0.325
Data Source: BioPlex,STRINGDB
UBR1
Tbio
Family: Enzyme
Novelty: 0.00998888
p_int: 0.999156196
p_ni: 0.000843804
Data Source: BioPlex
GGPS1
Tchem
Family: Enzyme
Novelty: 0.00292258
p_int: 0.994446901
p_ni: 0.005553098
p_wrong: 2e-9
Data Source: BioPlex
PRMT6
Tchem
Family: Epigenetic
Novelty: 0.01734208
p_int: 0.98584594
p_ni: 0.014154059
Data Source: BioPlex
Publication Statistics
PubMed Score  4721.83

PubMed score by year
PubTator Score  2876.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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