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Tbio
DENND6B
Protein DENND6B

Protein Summary
Description
Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000413817
  • ENSP00000391524
  • ENSG00000205593

Symbol
  • FAM116B
  • AFI1B
  • FAM116B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.92
transcription factor binding site profile
0.75
interacting protein
0.65
cell type or tissue
0.63
cell line
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.38   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 1
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
1
13.7
self reported educational attainment
1
1
1
13.7
intelligence
1
1
1
13.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
13.7
self reported educational attainment
1
13.7
intelligence
1
13.7
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
DENN domain containing 6B
715877
Mouse
MGI:1916690
69440
Rat
RGD:1308012
362983
Dog
DENN domain containing 6B
VGNC:54294
481192
Horse
DENN domain containing 6B
VGNC:17130
100056442
Species
Name
OMA
EggNOG
Inparanoid
Macaque
DENN domain containing 6B
Mouse
Rat
Dog
DENN domain containing 6B
Horse
DENN domain containing 6B
Pathways (4)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
RAB GEFs exchange GTP for GDP on RABs
Reactome
Rab regulation of trafficking
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
RAB GEFs exchange GTP for GDP on RABs
Rab regulation of trafficking
Vesicle-mediated transport
Gene Ontology Terms (3)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Protein-Protein Interactions (30)
1 – 10 of 30
DENND6A
Tbio
Novelty: 4.5572617
p_int: 0.999977319
p_wrong: 0.000022681
Data Source: BioPlex
GDI1
Tbio
Novelty: 0.01710945
Score: 0.905
Data Source: Reactome,STRINGDB
GDI2
Tbio
Novelty: 0.02861013
Score: 0.903
Data Source: Reactome,STRINGDB
CHML
Tbio
Family: Enzyme
Novelty: 0.00509709
Score: 0.902
Data Source: Reactome,STRINGDB
CHM
Tbio
Family: Enzyme
Novelty: 0.00226278
Score: 0.902
Data Source: Reactome,STRINGDB
RAB14
Tbio
Family: Enzyme
Novelty: 0.01876172
Score: 0.901
Data Source: Reactome,STRINGDB
FAM45A
Tdark
Novelty: 0.94034891
Score: 0.743
Data Source: STRINGDB
LCHN
Tdark
Novelty: 0.08678963
Score: 0.71
Data Source: STRINGDB
AVL9
Tbio
Novelty: 0.14044287
Score: 0.622
Data Source: STRINGDB
PPP6R2
Tbio
Family: Enzyme
Novelty: 0.12886225
Score: 0.594
Data Source: STRINGDB
Publication Statistics
PubMed Score  0.38

PubMed score by year
PubTator Score  0.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer