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Tbio
SEPT9
Septin-9

Protein Summary
Description
Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in the internalization of 2 intracellular microbial pathogens, Listeria monocytogenes and Shigella flexneri. This gene is a member of the septin family involved in cytokinesis and cell cycle control. This gene is a candidate for the ovarian tumor suppressor gene. Mutations in this gene cause hereditary neuralgic amyotrophy, also known as neuritis with brachial predilection. A chromosomal translocation involving this gene on chromosome 17 and the MLL gene on chromosome 11 results in acute myelomonocytic leukemia. Multiple alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000329047
  • ENSP00000329161
  • ENSG00000184640
  • ENST00000423034
  • ENSP00000405877
  • ENST00000427177
  • ENSP00000391249
  • ENST00000427180
  • ENSP00000415624
  • ENST00000427674
  • ENSP00000403194
  • ENST00000431235
  • ENSP00000406987
  • ENST00000449803
  • ENSP00000400181
  • ENST00000541152
  • ENSP00000438089
  • ENST00000585930
  • ENSP00000468120
  • ENST00000588690
  • ENSP00000468668
  • ENST00000590294
  • ENSP00000465464
  • ENST00000591088
  • ENSP00000466247
  • ENST00000591198
  • ENSP00000468406
  • ENST00000592951
  • ENSP00000466648

Symbol
  • KIAA0991
  • MSF
  • MSF
  • MSF1
  • NAPB
  • SINT1
  • PNUTL4
  • SeptD1
  • AF17q25
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.91
disease perturbation
0.83
kinase perturbation
0.81
transcription factor perturbation
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.04   (req: < 5)
Gene RIFs: 69   (req: <= 3)
Antibodies: 181   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 273.04   (req: >= 5)
Gene RIFs: 69   (req: > 3)
Antibodies: 181   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
95.7
intraocular pressure measurement
1
2
2
76.9
reticulocyte count
6
3
7
75.6
reticulocyte measurement
3
3
3
71.7
refractive error measurement
1
1
1
63.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
95.7
intraocular pressure measurement
2
76.9
reticulocyte count
7
75.6
reticulocyte measurement
3
71.7
refractive error measurement
1
63.8
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Gene Ontology Terms (20)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (93)
1 – 10 of 93
SEPT7
Tbio
Novelty: 0.00554708
p_int: 0.999993324
p_ni: 0.000006676
Score: 0.986
Data Source: BioPlex,STRINGDB
SEPT6
Tbio
Novelty: 0.00885503
p_int: 0.999952978
p_ni: 0.000047022
Score: 0.962
Data Source: BioPlex,STRINGDB
SEPT1
Tdark
Novelty: 0.04450119
p_int: 0.99995235
p_ni: 0.00004765
Score: 0.933
Data Source: BioPlex,STRINGDB
SEPT2
Tbio
Novelty: 0.01047916
p_int: 0.999917845
p_ni: 0.000082153
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,STRINGDB
SEPT10
Tbio
Novelty: 0.14834834
p_int: 0.999512563
p_ni: 0.000487437
Score: 0.879
Data Source: BioPlex,STRINGDB
SEPT3
Tbio
Novelty: 0.008513
p_int: 0.998788048
p_ni: 0.001211952
Score: 0.871
Data Source: BioPlex,STRINGDB
MRPL12
Tbio
Novelty: 0.10646542
p_int: 0.998218062
p_ni: 0.001781938
Score: 0.565
Data Source: BioPlex,STRINGDB
CDC42EP4
Tdark
Novelty: 0.27965905
p_int: 0.996182152
p_ni: 0.003817848
Score: 0.9
Data Source: BioPlex,STRINGDB
ACAP3
Tbio
Novelty: 0.19558023
p_int: 0.99202665
p_ni: 0.00797335
Data Source: BioPlex
CDC5L
Tbio
Family: TF
Novelty: 0.00663599
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  273.04

PubMed score by year
PubTator Score  163.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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