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Tbio
RDH13
Retinol dehydrogenase 13

Protein Summary
Description
Does not exhibit retinol dehydrogenase (RDH) activity in vitro. This gene encodes a mitochondrial short-chain dehydrogenase/reductase, which catalyzes the reduction and oxidation of retinoids. The encoded enzyme may function in retinoic acid production and may also protect the mitochondria against oxidative stress. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396247
  • ENSP00000379547
  • ENSG00000160439
  • ENST00000415061
  • ENSP00000391121
  • ENST00000610356
  • ENSP00000477732
  • ENST00000613257
  • ENSP00000479552
  • ENSG00000276341
  • ENST00000613935
  • ENSP00000482809
  • ENSG00000274504
  • ENST00000615256
  • ENSP00000477512
  • ENSG00000276684
  • ENST00000615688
  • ENSP00000482782
  • ENSG00000275474
  • ENST00000616348
  • ENSP00000477884
  • ENSG00000276826
  • ENST00000620423
  • ENSP00000482051
  • ENSG00000278149
  • ENST00000621614
  • ENSP00000484637
  • ENST00000621849
  • ENSP00000480095
  • ENSG00000273944
  • ENST00000622200
  • ENSP00000484111
  • ENSG00000274418
  • ENST00000622572
  • ENSP00000484246
  • ENSG00000278284

Symbol
  • SDR7C3
  • SDR7C3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.98
transcription factor
0.72
cell type or tissue
0.69
histone modification site profile
0.67
pathway
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.3   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 127   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.3   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 127   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
1
1
13.2
mean platelet volume
1
1
1
13.2
mean platelet volume
1
1
1
13.2
mean platelet volume
1
1
1
13.2
mean platelet volume
1
1
1
13.2
Items per page:
1 – 5 of 10
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean platelet volume
1
13.2
mean platelet volume
1
13.2
mean platelet volume
1
13.2
mean platelet volume
1
13.2
mean platelet volume
1
13.2
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 13
VGNC:13658
456293
Mouse
MGI:1918732
108841
Rat
RGD:1304959
361504
Dog
retinol dehydrogenase 13
VGNC:45453
611373
Horse
retinol dehydrogenase 13
VGNC:22280
100055280
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol dehydrogenase 13
Mouse
Rat
Dog
retinol dehydrogenase 13
Horse
retinol dehydrogenase 13
Pathways (4)
RA biosynthesis pathway (R-HSA-5365859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
RA biosynthesis pathway
Reactome
Signal Transduction
Reactome
Signaling by Nuclear Receptors
Reactome
Signaling by Retinoic Acid
Name
Explore in Pharos
Explore in Source
RA biosynthesis pathway
Signal Transduction
Signaling by Nuclear Receptors
Signaling by Retinoic Acid
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (65)
1 – 10 of 65
PROSER2
Tdark
Novelty: 0.56334611
p_int: 0.99982001
p_ni: 0.00017999
Data Source: BioPlex
EMILIN1
Tbio
Novelty: 0.02550566
p_int: 0.999140874
p_ni: 0.000859126
Data Source: BioPlex
PCDHB1
Tdark
Novelty: 0.93001191
p_int: 0.997682264
p_ni: 0.002317736
Data Source: BioPlex
CUEDC1
Tbio
Novelty: 0.14401061
p_int: 0.99704077
p_ni: 0.00295923
Data Source: BioPlex
TMEM208
Tdark
Novelty: 0.63059333
p_int: 0.996106589
p_ni: 0.003893411
Data Source: BioPlex
ZNF44
Tbio
Family: TF
Novelty: 0.00895101
p_int: 0.994496818
p_ni: 0.005503182
Score: 0.41
Data Source: BioPlex,STRINGDB
COPZ2
Tdark
Novelty: 0.21561497
p_int: 0.993701667
p_ni: 0.006293744
p_wrong: 0.000004589
Data Source: BioPlex
PCDHGA5
Tdark
Novelty: 2.13631603
p_int: 0.990616648
p_ni: 0.009383348
p_wrong: 4e-9
Data Source: BioPlex
LSM5
Tbio
Novelty: 0.12669584
p_int: 0.976806985
p_ni: 0.023193015
Score: 0.154
Data Source: BioPlex,STRINGDB
SLC27A4
Tchem
Family: Transporter
Novelty: 0.0143834
p_int: 0.974596487
p_ni: 0.02535168
p_wrong: 0.000051834
Data Source: BioPlex
Publication Statistics
PubMed Score  5.30

PubMed score by year
PubTator Score  1.96

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer