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Tclin
IDH1
Isocitrate dehydrogenase [NADP] cytoplasmic

Protein Summary
Description
Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation o ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000345146
  • ENSP00000260985
  • ENSG00000138413
  • ENST00000415913
  • ENSP00000390265
  • ENST00000446179
  • ENSP00000410513

Symbol
  • PICD
  • IDH
  • IDP
  • IDCD
  • IDPC
  • PICD
  • HEL-216
  • HEL-S-26
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
transcription factor perturbation
0.99
disease perturbation
0.93
kinase perturbation
0.91
transcription factor binding site profile
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2261.54   (req: < 5)
Gene RIFs: 585   (req: <= 3)
Antibodies: 843   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2261.54   (req: >= 5)
Gene RIFs: 585   (req: > 3)
Antibodies: 843   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 706
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
ivosidenib
chemical structure image
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
VGNC:1968
460113
Macaque
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
710019
Mouse
MGI:96413
15926
Rat
RGD:2862
24479
Dog
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
478889
Species
Name
OMA
EggNOG
Inparanoid
Chimp
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Macaque
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Mouse
Rat
Dog
isocitrate dehydrogenase (NADP(+)) 1, cytosolic
Protein Structure (36 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O75874-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 36
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate (R-HSA-2978092)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Reactome
Disease
Reactome
Diseases of metabolism
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Abnormal conversion of 2-oxoglutarate to 2-hydroxyglutarate
Disease
Diseases of metabolism
Immune System
Innate Immune System
Gene Ontology Terms (33)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (376)
1 – 10 of 376
IDH3B
Tbio
Family: Enzyme
Novelty: 0.04326765
Score: 0.995
Data Source: STRINGDB
IDH3G
Tbio
Family: Enzyme
Novelty: 0.04861242
Score: 0.995
Data Source: STRINGDB
IDH3A
Tbio
Family: Enzyme
Novelty: 0.02027198
Score: 0.989
Data Source: STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.987
Data Source: STRINGDB
ACO2
Tbio
Family: Enzyme
Novelty: 0.00276725
Score: 0.979
Data Source: STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00131782
Score: 0.976
Data Source: STRINGDB
ACO1
Tbio
Family: Enzyme
Novelty: 0.00194023
Score: 0.971
Data Source: STRINGDB
PGM1
Tbio
Family: Enzyme
Novelty: 0.00163947
Score: 0.964
Data Source: STRINGDB
HSD17B4
Tbio
Novelty: 0.00547499
Score: 0.957
Data Source: STRINGDB
CAT
Tbio
Family: Enzyme
Novelty: 0.00181888
Score: 0.951
Data Source: STRINGDB
Publication Statistics
PubMed Score  2261.54

PubMed score by year
PubTator Score  1729.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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