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Tbio
PLEKHM1
Pleckstrin homology domain-containing family M member 1

Protein Summary
Description
Proposed to act as a multivalent adapter protein that regulates Rab7-dependent and HOPS complex-dependent fusion events in the endolysosomal system and couples autophagic and the endocytic trafficking pathways. Required for late stages of endolysosomal maturation, facilitating both endocytosis-mediated degradation of growth factor receptors and autophagosome clearance. Seems to be involved in the terminal maturation of autophagosomes and to mediate autophagosome-lysosome fusion (PubMed:25498145). Positively regulates lysosome peripheral distribution and ruffled border formation in osteoclasts (By similarity). May be involved in negative regulation of endocytic transport from early endosome to late endosome/lysosome implicating its association with Rab7 (PubMed:20943950). May have a role in sialyl-lex-mediated transduction of apoptotic signals (PubMed:12820725). Involved in bone resorption (By similarity). In case of infection contributes to Salmonella typhimurium pathogenesis by suppor ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000430334
  • ENSP00000389913
  • ENSG00000225190
  • ENST00000613787
  • ENSP00000479066
  • ENSG00000277111
  • ENST00000617688
  • ENSP00000483820
  • ENSG00000276358

Symbol
  • KIAA0356
  • B2
  • AP162
  • OPTA3
  • OPTB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
0.82
tissue
0.75
protein domain
0.73
drug perturbation
0.71
microRNA
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.59   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 129   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 45.59   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 129   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
2
0
1.2
96.2
cognitive function measurement
3
2
3
95.9
neuroticism measurement
2
2
2
88.8
cortical surface area measurement
1
1
0
1003.2
88.3
heel bone mineral density
1
1
1
88.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
96.2
cognitive function measurement
3
95.9
neuroticism measurement
2
88.8
cortical surface area measurement
0
1003.2
88.3
heel bone mineral density
1
88.1
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RUN domain containing M1
VGNC:51717
454754
Mouse
MGI:2443207
353047
Rat
RGD:1308010
303584
Horse
pleckstrin homology and RUN domain containing M1
VGNC:49419
100050008
Pig
pleckstrin homology and RUN domain containing M1
100523462
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pleckstrin homology and RUN domain containing M1
Mouse
Rat
Horse
pleckstrin homology and RUN domain containing M1
Pig
pleckstrin homology and RUN domain containing M1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y4G2-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (11)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
MAP1LC3C
Tbio
Novelty: 0.04062334
Score: 0.879
Data Source: STRINGDB
SNX10
Tbio
Novelty: 0.04148958
Score: 0.794
Data Source: STRINGDB
OSTM1
Tbio
Novelty: 0.03033192
Score: 0.728
Data Source: STRINGDB
CLCN7
Tchem
Family: IC
Novelty: 0.00764796
Score: 0.679
Data Source: STRINGDB
TCIRG1
Tbio
Family: Enzyme
Novelty: 0.00814253
Score: 0.666
Data Source: STRINGDB
BRAP
Tbio
Novelty: 0.0285957
Score: 0.665
Data Source: STRINGDB
MPDU1
Tbio
Novelty: 0.04418336
Score: 0.628
Data Source: STRINGDB
STX17
Tbio
Novelty: 0.01788363
Score: 0.627
Data Source: STRINGDB
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
Score: 0.62
Data Source: STRINGDB
RAB7A
Tbio
Family: Enzyme
Novelty: 0.00192702
Score: 0.604
Data Source: STRINGDB
Publication Statistics
PubMed Score  45.59

PubMed score by year
PubTator Score  13.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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