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Tbio
DSN1
Kinetochore-associated protein DSN1 homolog

Protein Summary
Description
Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis. This gene encodes a kinetochore protein that functions as part of the minichromosome instability-12 centromere complex. The encoded protein is required for proper kinetochore assembly and progression through the cell cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373734
  • ENSP00000362839
  • ENSG00000149636
  • ENST00000373750
  • ENSP00000362855
  • ENST00000426836
  • ENSP00000389810
  • ENST00000448110
  • ENSP00000404463

Symbol
  • C20orf172
  • MIS13
  • KNL3
  • MIS13
  • hKNL-3
  • C20orf172
  • dJ469A13.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
transcription factor binding site profile
0.84
ligand (protein) perturbation
0.83
drug perturbation
0.71
hub protein
0.67


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.92   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 163   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 16.92   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 163   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
1
2
91.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
2
91.1
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal (R-HSA-141444)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Reactome
Amplification of signal from the kinetochores
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cell Cycle, Mitotic
Name
Explore in Pharos
Explore in Source
Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
Amplification of signal from the kinetochores
Cell Cycle
Cell Cycle Checkpoints
Cell Cycle, Mitotic
Gene Ontology Terms (15)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
WormBase
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (244)
1 – 10 of 244
ZWINT
Tbio
Novelty: 0.02153276
p_int: 1
Score: 0.999
Data Source: BioPlex,STRINGDB
NSL1
Tbio
Novelty: 0.01396984
p_int: 1
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
SPC25
Tbio
Novelty: 0.26354244
p_int: 1
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
PMF1
Tbio
Novelty: 0.05319446
p_int: 1
Score: 0.982
Data Source: BioPlex,Reactome,STRINGDB
SPC24
Tbio
Novelty: 0.03166479
p_int: 0.999999999
p_ni: 1e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
MIS12
Tbio
Novelty: 0.05345698
p_int: 0.999999698
p_ni: 3.02e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
KNL1
Tbio
Novelty: 0.01084826
p_int: 0.999998866
p_ni: 0.000001134
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
NDC80
Tbio
Novelty: 0.00331814
p_int: 0.999993254
p_ni: 0.000006742
p_wrong: 4e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
NUF2
Tbio
Novelty: 0.01069726
p_int: 0.999985187
p_ni: 0.000014813
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
TPST2
Tbio
Family: Enzyme
Novelty: 0.02551048
p_int: 0.999757065
p_ni: 0.000242935
Data Source: BioPlex
Publication Statistics
PubMed Score  16.92

PubMed score by year
PubTator Score  5.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer