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Tbio
PLEKHF1
Pleckstrin homology domain-containing family F member 1

Protein Summary
Description
May induce apoptosis through the lysosomal-mitochondrial pathway. Translocates to the lysosome initiating the permeabilization of lysosomal membrane (LMP) and resulting in the release of CTSD and CTSL to the cytoplasm. Triggers the caspase-independent apoptosis by altering mitochondrial membrane permeabilization (MMP) resulting in the release of PDCD8.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000436066
  • ENSP00000389787
  • ENSG00000166289
  • ENST00000592810
  • ENSP00000466292

Symbol
  • APPD
  • LAPF
  • ZFYVE15
  • APPD
  • LAPF
  • PHAFIN1
  • ZFYVE15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.89
protein domain
0.85
histone modification site profile
0.71
transcription factor binding site profile
0.71
small molecule perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.18   (req: < 5)
Gene RIFs: 2   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.18   (req: >= 5)
Gene RIFs: 2   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (16)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (37)
1 – 10 of 37
VSTM2B
Tdark
Novelty: 2.55319149
Score: 0.631
Data Source: STRINGDB
NDFIP2
Tbio
Novelty: 0.18701993
Score: 0.616
Data Source: STRINGDB
DYRK2
Tchem
Family: Kinase
Novelty: 0.02235572
Score: 0.577
Data Source: STRINGDB
NIN
Tbio
Novelty: 0.00202262
Score: 0.563
Data Source: STRINGDB
POP4
Tbio
Family: Enzyme
Novelty: 0.02434459
Score: 0.554
Data Source: STRINGDB
SMDT1
Tbio
Novelty: 0.02130362
Score: 0.554
Data Source: STRINGDB
C19orf12
Tbio
Novelty: 0.03016916
Score: 0.54
Data Source: STRINGDB
RBM24
Tbio
Novelty: 0.05713269
Score: 0.533
Data Source: STRINGDB
PIKFYVE
Tchem
Family: Kinase
Novelty: 0.00543103
Score: 0.512
Data Source: STRINGDB
CAVIN2
Tbio
Novelty: 0.00123683
Score: 0.51
Data Source: STRINGDB
Publication Statistics
PubMed Score  71.18

PubMed score by year
PubTator Score  7.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer