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Tbio
TLR6
Toll-like receptor 6

Protein Summary
Description
Participates in the innate immune response to Gram-positive bacteria and fungi. Specifically recognizes diacylated and, to a lesser extent, triacylated lipopeptides (PubMed:20037584). In response to diacylated lipopeptides, forms the activation cluster TLR2:TLR6:CD14:CD36, this cluster triggers signaling from the cell surface and subsequently is targeted to the Golgi in a lipid-raft dependent pathway (PubMed:16880211). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR2 (PubMed:11441107). In complex with TLR4, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000381950
  • ENSP00000371376
  • ENSG00000174130
  • ENST00000436693
  • ENSP00000389600
  • ENST00000610323
  • ENSP00000480266

Symbol
  • CD286
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.93
gene perturbation
0.85
biological term
0.77
protein domain
0.73
tissue sample
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.72   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 821   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 211.72   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 821   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.1
57.3
1
1
0
1.1
57.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
57.3
0
1.1
57.3
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 6
VGNC:12862
471167
Macaque
toll like receptor 6
574342
Mouse
MGI:1341296
21899
Rat
RGD:1303030
305353
Dog
toll like receptor 6
VGNC:53249
111089957
Species
Name
OMA
EggNOG
Inparanoid
Chimp
toll like receptor 6
Macaque
toll like receptor 6
Mouse
Rat
Dog
toll like receptor 6
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9Y2C9-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (56)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Disease
Reactome
Diseases associated with the TLR signaling cascade
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Disease
Diseases associated with the TLR signaling cascade
Gene Ontology Terms (47)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (298)
1 – 10 of 298
TLR1
Tbio
Novelty: 0.00171909
p_int: 0.999999992
p_wrong: 9e-9
Score: 0.95
Data Source: BioPlex,STRINGDB
IQUB
Tdark
Novelty: 0.11732563
p_int: 0.998579484
p_ni: 0.000064744
p_wrong: 0.001355771
Score: 0.688
Data Source: BioPlex,STRINGDB
MYD88
Tbio
Novelty: 0.00037931
Score: 0.991
Data Source: Reactome,STRINGDB
TLR2
Tchem
Novelty: 0.00023242
Score: 0.978
Data Source: Reactome,STRINGDB
IRAK1
Tchem
Family: Kinase
Novelty: 0.00170873
Score: 0.974
Data Source: Reactome,STRINGDB
TRAF6
Tbio
Novelty: 0.00109366
Score: 0.971
Data Source: Reactome,STRINGDB
TLR4
Tchem
Novelty: 0.00010863
Score: 0.958
Data Source: Reactome,STRINGDB
IKBKG
Tbio
Family: Kinase
Novelty: 0.0006149
Score: 0.957
Data Source: STRINGDB
CD14
Tbio
Novelty: 0.00872424
Score: 0.948
Data Source: Reactome,STRINGDB
VCAN
Tbio
Novelty: 0.00110986
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  211.72

PubMed score by year
PubTator Score  177.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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