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Tchem
CHEK1
Serine/threonine-protein kinase Chk1

Protein Summary
Description
Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. This regulation is achieved by a number of mechanisms that together help to preserve the integrity of the genome. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88' by NEK11, which is required for polyubiquitination and degradation of CDCD25A. Inhibition of CD ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000428830
  • ENSP00000412504
  • ENSG00000149554
  • ENST00000438015
  • ENSP00000388648
  • ENST00000524737
  • ENSP00000432890
  • ENST00000532449
  • ENSP00000481616
  • ENST00000534070
  • ENSP00000435371
  • ENST00000544373
  • ENSP00000442317

Symbol
  • CHK1
  • CHK1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
1
biological process
0.99
drug perturbation
0.99
interacting protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1541.32   (req: < 5)
Gene RIFs: 355   (req: <= 3)
Antibodies: 1665   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1541.32   (req: >= 5)
Gene RIFs: 355   (req: > 3)
Antibodies: 1665   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 859
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (859)
1 – 10 of 859
CHEMBL388978
chemical structure image
CHEMBL603469
chemical structure image
CHEMBL1236539
chemical structure image
CHEMBL248757
chemical structure image
CHEMBL3923888
chemical structure image
CHEMBL1232515,CHEMBL1650533
chemical structure image
CHEMBL3916849
chemical structure image
CHEMBL2203843
chemical structure image
CHEMBL2041933
chemical structure image
Protein Data Bank (133)
1 – 5 of 133
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (52)
Activation of ATR in response to replication stress (R-HSA-176187)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 29
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of ATR in response to replication stress
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
Reactome
DNA Double-Strand Break Repair
Name
Explore in Pharos
Explore in Source
Activation of ATR in response to replication stress
Cell Cycle
Cell Cycle Checkpoints
Chk1/Chk2(Cds1) mediated inactivation of Cyclin B:Cdk1 complex
DNA Double-Strand Break Repair
Gene Ontology Terms (38)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
CAFA
Inferred from Mutant Phenotype (IMP)
CACAO
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (560)
1 – 10 of 560
CHRNA9
Tchem
Family: IC
Novelty: 0.05009815
p_int: 0.999971987
p_ni: 0.000028006
p_wrong: 7e-9
Score: 0.156
Data Source: BioPlex,STRINGDB
HDAC6
Tclin
Family: Epigenetic
Novelty: 0.00122232
p_int: 0.999452122
p_ni: 0.000547878
Score: 0.256
Data Source: BioPlex,STRINGDB
NAT9
Tbio
Family: Enzyme
Novelty: 0.07036821
p_int: 0.998469685
p_ni: 0.001530315
Score: 0.228
Data Source: BioPlex,STRINGDB
DDHD1
Tbio
Family: Enzyme
Novelty: 0.05209502
p_int: 0.997014342
p_ni: 0.002985658
Data Source: BioPlex
ERCC6L
Tbio
Novelty: 0.01959203
p_int: 0.995981915
p_ni: 0.004018079
p_wrong: 6e-9
Score: 0.641
Data Source: BioPlex,STRINGDB
IL13RA2
Tbio
Novelty: 0.03465642
p_int: 0.994315479
p_ni: 0.005684521
Data Source: BioPlex
TCEAL1
Tbio
Novelty: 0.02210924
p_int: 0.986318774
p_ni: 0.013681219
p_wrong: 6e-9
Score: 0.228
Data Source: BioPlex,STRINGDB
RNF181
Tbio
Family: Enzyme
Novelty: 0.27482636
p_int: 0.985224669
p_ni: 0.014775306
p_wrong: 2.4e-8
Data Source: BioPlex
LRRC6
Tbio
Novelty: 0.10994386
p_int: 0.968617994
p_ni: 0.031382004
p_wrong: 2e-9
Score: 0.193
Data Source: BioPlex,STRINGDB
BCL2L14
Tbio
Novelty: 0.03980069
p_int: 0.940957502
p_ni: 0.059042498
Score: 0.206
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1541.32

PubMed score by year
PubTator Score  1106.88

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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