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Tdark
CTU2
Cytoplasmic tRNA 2-thiolation protein 2

Protein Summary
Description
Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. This gene encodes a protein which is involved in the post-transcriptional modification of transfer RNAs (tRNAs). The encoded protein plays a role in thiolation of uridine residue present at the wobble position in a subset of tRNAs, resulting in enhanced codon reading accuracy. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000312060
  • ENSP00000308617
  • ENSG00000174177
  • ENST00000453996
  • ENSP00000388320

Symbol
  • C16orf84
  • NCS2
  • MFRG
  • NCS2
  • UPF0432
  • C16orf84
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.68
cell line
0.63
tissue sample
0.63
transcription factor binding site profile
0.6
transcription factor perturbation
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.11   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 19   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 107.11   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 19   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
25.9
platelet crit
1
1
1
20.9
feeling "fed-up" measurement
1
1
0
5.5
11.5
hemoglobin measurement
1
1
1
9.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
25.9
platelet crit
1
20.9
feeling "fed-up" measurement
0
5.5
11.5
hemoglobin measurement
1
9.5
Pathways (5)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (64)
1 – 10 of 64
LBHD1
Tdark
Novelty: 7.69709763
p_int: 0.997274633
p_ni: 0.002725367
Score: 0.169
Data Source: BioPlex,STRINGDB
TINAG
Tbio
Novelty: 0.04582927
p_int: 0.994865536
p_ni: 0.005134464
Data Source: BioPlex
SCPEP1
Tbio
Family: Enzyme
Novelty: 0.08603794
p_int: 0.992985705
p_ni: 0.007014294
p_wrong: 1e-9
Data Source: BioPlex
MYCL
Tbio
Family: TF
Novelty: 0.0034508
p_int: 0.987067533
p_ni: 0.012932467
Data Source: BioPlex
THUMPD3
Tdark
Novelty: 0.23224828
p_int: 0.966379166
p_ni: 0.033620834
Score: 0.176
Data Source: BioPlex,STRINGDB
PAFAH2
Tbio
Family: Enzyme
Novelty: 0.19881779
p_int: 0.957353941
p_ni: 0.042646035
p_wrong: 2.4e-8
Data Source: BioPlex
ZMAT5
Tdark
Novelty: 0.97115324
p_int: 0.950170017
p_ni: 0.049829983
Data Source: BioPlex
CCDC120
Tbio
Novelty: 0.48574876
p_int: 0.940353986
p_ni: 0.05964597
p_wrong: 4.4e-8
Data Source: BioPlex
PFDN4
Tbio
Novelty: 0.02133605
p_int: 0.93157936
p_ni: 0.06842064
Data Source: BioPlex
POLM
Tbio
Family: Enzyme
Novelty: 0.00362931
p_int: 0.920836162
p_ni: 0.079163838
Score: 0.204
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  107.11

PubMed score by year
PubTator Score  146.12

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer