Tdark ZNF845 Zinc finger protein 845

Protein Summary

Description

May be involved in transcriptional regulation.

Uniprot Accession IDs

• Q96IR2

Gene Name

• ZNF845

Ensembl ID

• ENST00000458035
• ENSP00000388311
• ENSG00000213799
• ENST00000595091
• ENSP00000470005

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
histone modification site profile	0.75
cell line	0.66
protein domain	0.58
microRNA	0.51
transcription factor	0.47

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: < 5)

Gene RIFs: 0   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 0.23   (req: >= 5)

Gene RIFs: 0   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (1)

KEGG (1)

Items per page:

5

1 – 1 of 1

Data Source	Name	Explore in Pharos	Explore in Source
KEGG	Herpes simplex virus 1 infection	567 targets	path:hsa05168

Name	Explore in Pharos	Explore in Source
Herpes simplex virus 1 infection	567 targets	path:hsa05168

Gene Ontology Terms (4)

Functions (3)

Components (1)

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
DNA binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (11)

Explore Interacting Targets

1 – 10 of 11

• See Interactions on String-DB

TRIM28

Tbio

Family: Epigenetic

Novelty: 0.01042773

p_int: 0.999975099

p_ni: 0.000008941

p_wrong: 0.000015959

Score: 0.257

Data Source: BioPlex,STRINGDB

GPATCH4

Tdark

Novelty: 2.35294118

p_int: 0.999910069

p_ni: 0.00008105

p_wrong: 0.000008881

Data Source: BioPlex

SART3

Tbio

Novelty: 0.02812047

p_int: 0.967571701

p_ni: 0.000286358

p_wrong: 0.032141941

Data Source: BioPlex

DAP3

Tbio

Novelty: 0.0575752

Score: 0.616

Data Source: STRINGDB

SERGEF

Tdark

Novelty: 0.55408971

Score: 0.55

Data Source: STRINGDB

OR4N4

Tdark

Family: oGPCR

Novelty: 1.15384615

Score: 0.548

Data Source: STRINGDB

PLPP4

Tbio

Family: Enzyme

Novelty: 0.36878578

Score: 0.496

Data Source: STRINGDB

LRRC1

Tbio

Novelty: 0.06567933

Score: 0.447

Data Source: STRINGDB

SEC23IP

Tbio

Novelty: 0.13247818

Score: 0.447

Data Source: STRINGDB

NDUFAF1

Tclin

Novelty: 0.0776632

Score: 0.41

Data Source: STRINGDB

Publication Statistics

PubMed Score  0.23

PubMed score by year

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PubTator Score  0.17

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNTEVIH

1-70

TGTLQRHERHHIGDFCFQEMEKDIHDFEFQWKEDERNSHEAPMTEIKQLTGSTNRHDQRHAGNKPIKDQL

70-140

GSSFHSHLPELHMFQTEGKIGNQVEKSINSASLVSTSQRISCRPKTHISKNYGNNFLNSSLLTQKQEVHM

140-210

REKSFQCNESGKAFNYSSVLRKHQIIHLGAKQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCNDCGKTF

210-280

SQELTLTCHHRLHTGEKHYKCSECGKTFSRNSALVIHKAIHTGEKSYKCNECGKTFSQTSYLVYHRRLHT

280-350

GEKPYKCEECDKAFSFKSNLERHRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCNDCGKTF

350-420

SQMSSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHT

420-490

GEKPYKCEECDEAFSFKSNLERHRIIHTGEKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAF

490-560

RGQSALIYHQAIHGIGKLYKCNDCHQVFSNATTIANHWRIHNEERSYKCNRCGKFFRHRSYLAVHWRTHS

560-630

GEKPYKCEECDEAFSFKSNLQRHRRIHTGEKPYRCNECGKTFSRKSYLTCHRRLHTGEKPYKCNECGKTF

630-700

GRNSALIIHKAIHTGEKPYKCNECGKAFSQKSSLTCHLRLHTGEKPYKCEECDKVFSRKSSLEKHRRIHT

700-770

GEKPYKCKVCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFRHNSALVIHKAIHSGEKPYKCNECGKTF

770-840

RHNSALEIHKAIHTGEKPYKCSECGKVFNRKANLSRHHRLHTGEKPYKCNKCGKVFNQQAHLACHHRIHT

840-910

GEKPYKCNECGKTFRHNSVLVIHKTIHTGEKPYKCNECGKVFNRKAKLARHHRIHTGKKH

910-970

MALSQGLLTFRDVAIEFSQEEWKCLDPAQRTLYRDVMLENYRNLVSLDISSKCMMKEFSSTAQGNTEVIHTGTLQRHERHHIGDFCFQEMEKDIHDFEFQWKEDERNSHEAPMTEIKQLTGSTNRHDQRHAGNKPIKDQLGSSFHSHLPELHMFQTEGKIGNQVEKSINSASLVSTSQRISCRPKTHISKNYGNNFLNSSLLTQKQEVHMREKSFQCNESGKAFNYSSVLRKHQIIHLGAKQYKCDVCGKVFNQKRYLACHRRCHTGKKPYKCNDCGKTFSQELTLTCHHRLHTGEKHYKCSECGKTFSRNSALVIHKAIHTGEKSYKCNECGKTFSQTSYLVYHRRLHTGEKPYKCEECDKAFSFKSNLERHRKIHTGEKPYKCNECSRTFSRKSSLTRHRRLHTGEKPYKCNDCGKTFSQMSSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRRIHTGEKPYKCNDCGKTFSQTSSLVYHRRLHTGEKPYKCEECDEAFSFKSNLERHRIIHTGEKLYKCNECGKTFSRKSSLTRHCRLHTGEKPYQCNECGKAFRGQSALIYHQAIHGIGKLYKCNDCHQVFSNATTIANHWRIHNEERSYKCNRCGKFFRHRSYLAVHWRTHSGEKPYKCEECDEAFSFKSNLQRHRRIHTGEKPYRCNECGKTFSRKSYLTCHRRLHTGEKPYKCNECGKTFGRNSALIIHKAIHTGEKPYKCNECGKAFSQKSSLTCHLRLHTGEKPYKCEECDKVFSRKSSLEKHRRIHTGEKPYKCKVCDKAFGRDSHLAQHTRIHTGEKPYKCNECGKNFRHNSALVIHKAIHSGEKPYKCNECGKTFRHNSALEIHKAIHTGEKPYKCSECGKVFNRKANLSRHHRLHTGEKPYKCNKCGKVFNQQAHLACHHRIHTGEKPYKCNECGKTFRHNSVLVIHKTIHTGEKPYKCNECGKVFNRKAKLARHHRIHTGKKH

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Uniprot Keyword

Complete proteome
DNA-binding
Isopeptide bond
Metal-binding
Nucleus
Reference proteome
Repeat
Transcription
Transcription regulation
Ubl conjugation