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Tbio
ARPC4
Actin-related protein 2/3 complex subunit 4

Protein Summary
Description
Actin-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). This gene encodes one of seven subunits of the human Arp2/3 protein complex. This complex controls actin polymerization in cells and has been conserved throughout eukaryotic evolution. This gene encodes the p20 subunit, which is necessary for actin nucleation ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000397261
  • ENSP00000380431
  • ENSG00000241553
  • ENST00000433034
  • ENSP00000388169
  • ENST00000498623
  • ENSP00000432235

Symbol
  • ARC20
  • ARC20
  • P20-ARC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.93
kinase perturbation
0.88
histone modification site profile
0.78
transcription factor binding site profile
0.76
disease
0.69


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.23   (req: < 5)
Gene RIFs: 4   (req: <= 3)
Antibodies: 185   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.23   (req: >= 5)
Gene RIFs: 4   (req: > 3)
Antibodies: 185   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 4
VGNC:11324
100614809
Mouse
MGI:1915339
68089
Rat
RGD:1310096
297518
Dog
actin related protein 2/3 complex subunit 4
VGNC:54574
106560075
Horse
actin related protein 2/3 complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:707]
106781783
Species
Name
OMA
EggNOG
Inparanoid
Chimp
actin related protein 2/3 complex subunit 4
Mouse
Rat
Dog
actin related protein 2/3 complex subunit 4
Horse
actin related protein 2/3 complex subunit 4 [Source:HGNC Symbol;Acc:HGNC:707]
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P59998-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (30)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
EPH-Ephrin signaling
Reactome
EPHB-mediated forward signaling
Name
Explore in Pharos
Explore in Source
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
EPH-Ephrin signaling
EPHB-mediated forward signaling
Gene Ontology Terms (15)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
FlyBase
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (207)
1 – 10 of 207
ACTR3B
Tbio
Novelty: 0.06033214
p_int: 0.988824033
p_ni: 0.011175967
Score: 0.981
Data Source: BioPlex,STRINGDB
ARPC1B
Tbio
Novelty: 0.03873325
p_int: 0.954586869
p_ni: 0.045413131
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR3
Tbio
Novelty: 0.02112745
p_int: 0.890789759
p_ni: 0.109210241
Score: 0.999
Data Source: BioPlex,STRINGDB
ACTR2
Tbio
Novelty: 0.00731489
Score: 0.999
Data Source: STRINGDB
ARPC1A
Tbio
Novelty: 0.07577807
Score: 0.999
Data Source: STRINGDB
ARPC5
Tbio
Novelty: 0.03434234
Score: 0.999
Data Source: STRINGDB
ARPC2
Tbio
Novelty: 0.02478791
Score: 0.999
Data Source: STRINGDB
ARPC5L
Tdark
Novelty: 0.35566409
Score: 0.999
Data Source: STRINGDB
ARPC3
Tbio
Novelty: 0.02951522
Score: 0.999
Data Source: STRINGDB
WASL
Tbio
Novelty: 0.0029314
Score: 0.994
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.23

PubMed score by year
PubTator Score  11.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer