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Tbio
WDR73
WD repeat-containing protein 73

Protein Summary
Description
May play a role in the regulation of microtubule organization and dynamics (PubMed:25466283). The protein encoded by this gene is thought to contain multiple WD40 repeats. WD40 repeats are motifs that contain 40-60 amino acids, and usually end with Trp-Asp (WD). This protein is found in the cytoplasm during interphase, but accumulates at the spindle poles and astral microtubules during mitosis. Reduced expression of this gene results in abnormalities in the size and morphology of the nucleus. Mutations in this gene have been associated with Galloway-Mowat syndrome PMID: 25466283), which is a rare autosomal recessive disorder that affects both the central nervous system and kidneys. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000434634
  • ENSP00000387982
  • ENSG00000177082

Symbol
  • GAMOS
  • GAMOS1
  • HSPC264
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.88
cell type or tissue
0.77
histone modification site profile
0.66
tissue sample
0.62
transcription factor binding site profile
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.81   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 80   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 27.81   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 80   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (79)
1 – 10 of 79
ANKRD36
Tdark
Novelty: 1.10032362
p_int: 0.997188039
p_ni: 0.002811894
p_wrong: 6.8e-8
Data Source: BioPlex
ALDH3B1
Tbio
Family: Enzyme
Novelty: 0.05626574
p_int: 0.991496027
p_ni: 0.008503391
p_wrong: 5.82e-7
Score: 0.195
Data Source: BioPlex,STRINGDB
DNAJC11
Tbio
Novelty: 0.56589907
p_int: 0.912660803
p_ni: 0.087339096
p_wrong: 1e-7
Score: 0.295
Data Source: BioPlex,STRINGDB
HDAC7
Tclin
Family: Epigenetic
Novelty: 0.00838044
p_int: 0.881544693
p_ni: 0.118455109
p_wrong: 1.99e-7
Score: 0.496
Data Source: BioPlex,STRINGDB
RFPL2
Tdark
Novelty: 6
p_int: 0.845629481
p_ni: 0.154370049
p_wrong: 4.69e-7
Score: 0.253
Data Source: BioPlex,STRINGDB
SLC2A14
Tbio
Family: Transporter
Novelty: 0.003532
p_int: 0.799900731
p_ni: 0.200091945
p_wrong: 0.000007324
Score: 0.345
Data Source: BioPlex,STRINGDB
HAT1
Tbio
Family: Epigenetic
Novelty: 0.04562033
Score: 0.833
Data Source: STRINGDB
EED
Tchem
Novelty: 0.00129663
Score: 0.784
Data Source: STRINGDB
TTC19
Tbio
Novelty: 0.09680022
Score: 0.747
Data Source: STRINGDB
RBM34
Tdark
Novelty: 1.05263158
Score: 0.739
Data Source: STRINGDB
Publication Statistics
PubMed Score  27.81

PubMed score by year
PubTator Score  9.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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