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Tchem
GCG
Glucagon

Protein Summary
Description
Glucagon plays a key role in glucose metabolism and homeostasis. Regulates blood glucose by increasing gluconeogenesis and decreasing glycolysis. A counterregulatory hormone of insulin, raises plasma glucose levels in response to insulin-induced hypoglycemia. Plays an important role in initiating and maintaining hyperglycemic conditions in diabetes. GLP-1 is a potent stimulator of glucose-dependent insulin release. Play important roles on gastric motility and the suppression of plasma glucagon levels. May be involved in the suppression of satiety and stimulation of glucose disposal in peripheral tissues, independent of the actions of insulin. Have growth-promoting activities on intestinal epithelium. May also regulate the hypothalamic pituitary axis (HPA) via effects on LH, TSH, CRH, oxytocin, and vasopressin secretion. Increases islet mass through stimulation of islet neogenesis and pancreatic beta cell proliferation. Inhibits beta cell apoptosis. GLP-2 stimulates intestinal growth an ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000375497
  • ENSP00000364647
  • ENSG00000115263
  • ENST00000418842
  • ENSP00000387662

Symbol
  • GLP1
  • GLP2
  • GRPP
  • GLP-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
0.98
chemical
0.8
disease
0.68
cellular component
0.67


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20622.08   (req: < 5)
Gene RIFs: 242   (req: <= 3)
Antibodies: 1735   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 20622.08   (req: >= 5)
Gene RIFs: 242   (req: > 3)
Antibodies: 1735   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 102
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glucagon
VGNC:439
100609153
Mouse
MGI:95674
14526
Rat
RGD:2668
24952
Dog
glucagon
VGNC:41143
403571
Horse
glucagon
VGNC:18274
100051551
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glucagon
Mouse
Rat
Dog
glucagon
Horse
glucagon
Protein Structure (17 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01275-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 17
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (32)
Class B/2 (Secretin family receptors) (R-HSA-373080)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class B/2 (Secretin family receptors)
Reactome
G alpha (q) signalling events
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Class B/2 (Secretin family receptors)
G alpha (q) signalling events
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Protein-Protein Interactions (518)
1 – 10 of 518
NDUFB8
Tclin
Family: Enzyme
Novelty: 0.019021
p_int: 0.999999256
p_ni: 7.23e-7
p_wrong: 2.1e-8
Data Source: BioPlex
ARMC8
Tbio
Novelty: 0.06820746
p_int: 0.999828277
p_ni: 0.000171723
Data Source: BioPlex
RANBP10
Tbio
Novelty: 0.10818049
p_int: 0.999689405
p_ni: 0.000310596
Data Source: BioPlex
WDR26
Tbio
Novelty: 0.04140166
p_int: 0.999670849
p_ni: 0.000329152
Data Source: BioPlex
RMND5A
Tbio
Novelty: 0.01820349
p_int: 0.999515145
p_ni: 0.000484855
Data Source: BioPlex
ZMYND19
Tdark
Novelty: 0.3590069
p_int: 0.999353174
p_ni: 0.000646826
Data Source: BioPlex
MKLN1
Tbio
Novelty: 0.05014385
p_int: 0.999144602
p_ni: 0.000855398
Data Source: BioPlex
GID4
Tbio
Novelty: 0.05252674
p_int: 0.999036121
p_ni: 0.000963879
Data Source: BioPlex
RMND5B
Tbio
Novelty: 0.08447048
p_int: 0.998916546
p_ni: 5.86e-7
p_wrong: 0.001082868
Data Source: BioPlex
MAEA
Tbio
Novelty: 0.00833813
p_int: 0.997263282
p_ni: 0.002736718
Data Source: BioPlex
Publication Statistics
PubMed Score  20622.08

PubMed score by year
PubTator Score  2915.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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