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Tbio
FUT2
Galactoside 2-alpha-L-fucosyltransferase 2

Protein Summary
Description
Mediates the transfer of fucose to the terminal galactose on glycan chains of cell surface glycoproteins and glycolipids (PubMed:7876235). The resulting epitope plays a role in cell-cell interaction including host-microbe interaction (PubMed:12692541, PubMed:8018146). Mediates interaction with intestinal microbiota influencing its composition (PubMed:21625510, PubMed:24733310, PubMed:22068912). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:7876235). The protein encoded by this gene is a Golgi stack membrane protein that is involved in the creation of a precursor of the H antigen, which is required for the final step in the soluble A and B antigen synthesis pathway. This gene is one of two encoding the galactoside 2-L-fucosyltransferase enzyme. Two transcript variants encoding the same protein have been found for this gene. [pro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391876
  • ENSP00000375748
  • ENSG00000176920
  • ENST00000425340
  • ENSP00000387498

Symbol
  • SEC2
  • SE
  • Se2
  • sej
  • SEC2
  • B12QTL1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.93
kinase perturbation
0.81
phenotype
0.78
cellular component
0.74
disease
0.73


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1104.74   (req: < 5)
Gene RIFs: 78   (req: <= 3)
Antibodies: 139   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1104.74   (req: >= 5)
Gene RIFs: 78   (req: > 3)
Antibodies: 139   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin B12 measurement
3
3
2
70.2
99.2
low density lipoprotein cholesterol measurement
4
5
9
96.6
C-reactive protein measurement
1
1
1
94.3
cancer biomarker measurement
1
1
2
92.7
total cholesterol measurement
2
3
7
90.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin B12 measurement
2
70.2
99.2
low density lipoprotein cholesterol measurement
9
96.6
C-reactive protein measurement
1
94.3
cancer biomarker measurement
2
92.7
total cholesterol measurement
7
90.6
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 2
VGNC:11109
468944
Mouse
MGI:109374
14344
Mouse
MGI:1928893
56546
Rat
RGD:2639
58924
Rat
RGD:1562499
308586
Species
Name
OMA
EggNOG
Inparanoid
Chimp
fucosyltransferase 2
Mouse
Mouse
Rat
Rat
Pathways (10)
ABO blood group biosynthesis (R-HSA-9033807)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ABO blood group biosynthesis
Reactome
Blood group systems biosynthesis
Reactome
Lewis blood group biosynthesis
Reactome
Metabolism
Reactome
Metabolism of carbohydrates
Name
Explore in Pharos
Explore in Source
ABO blood group biosynthesis
Blood group systems biosynthesis
Lewis blood group biosynthesis
Metabolism
Metabolism of carbohydrates
Protein-Protein Interactions (110)
1 – 10 of 110
FUT3
Tbio
Family: Enzyme
Novelty: 0.0059835
Score: 0.983
Data Source: STRINGDB
FUT5
Tbio
Family: Enzyme
Novelty: 0.0272442
Score: 0.976
Data Source: STRINGDB
FUT6
Tchem
Family: Enzyme
Novelty: 0.0123682
Score: 0.971
Data Source: STRINGDB
FUT4
Tbio
Family: Enzyme
Novelty: 0.00060869
Score: 0.97
Data Source: STRINGDB
ABO
Tbio
Family: Enzyme
Novelty: 0.01179347
Score: 0.966
Data Source: STRINGDB
FUT9
Tbio
Family: Enzyme
Novelty: 0.02880554
Score: 0.959
Data Source: STRINGDB
B3GALT5
Tbio
Family: Enzyme
Novelty: 0.04158039
Score: 0.958
Data Source: STRINGDB
ST3GAL4
Tbio
Family: Enzyme
Novelty: 0.00419433
Score: 0.946
Data Source: STRINGDB
B3GALT1
Tbio
Family: Enzyme
Novelty: 0.14518755
Score: 0.946
Data Source: STRINGDB
ST3GAL1
Tchem
Family: Enzyme
Novelty: 0.01236776
Score: 0.946
Data Source: STRINGDB
Publication Statistics
PubMed Score  1104.74

PubMed score by year
PubTator Score  608.66

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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