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Tbio
ACAN
Aggrecan core protein

Protein Summary
Description
This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000352105
  • ENSP00000341615
  • ENSG00000157766
  • ENST00000439576
  • ENSP00000387356
  • ENST00000559004
  • ENSP00000453499
  • ENST00000561243
  • ENSP00000453342

Symbol
  • AGC1
  • CSPG1
  • MSK16
  • AGC1
  • SEDK
  • AGCAN
  • CSPG1
  • MSK16
  • CSPGCP
  • SSOAOD
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.8
phenotype
0.71
pathway
0.66
cellular component
0.65
disease
0.57


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2904.41   (req: < 5)
Gene RIFs: 99   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2904.41   (req: >= 5)
Gene RIFs: 99   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
2
5
98.6
body height
7
9
10
96
body fat distribution
3
2
12
84.3
anthropometric measurement
1
1
0
1.2
58.5
BMI-adjusted waist circumference
3
2
5
44.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
appendicular lean mass
5
98.6
body height
10
96
body fat distribution
12
84.3
anthropometric measurement
0
1.2
58.5
BMI-adjusted waist circumference
5
44.1
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (19)
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d) (R-HSA-3656244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Reactome
Defective CHST6 causes MCDC1
Reactome
Defective ST3GAL3 causes MCT12 and EIEE15
Reactome
Degradation of the extracellular matrix
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Defective CHST6 causes MCDC1
Defective ST3GAL3 causes MCT12 and EIEE15
Degradation of the extracellular matrix
Disease
Gene Ontology Terms (26)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (244)
1 – 10 of 244
ADAMTS4
Tchem
Family: Enzyme
Novelty: 0.00424194
Score: 0.993
Data Source: Reactome,STRINGDB
ADAMTS5
Tchem
Family: Enzyme
Novelty: 0.00364004
Score: 0.993
Data Source: Reactome,STRINGDB
MMP3
Tchem
Novelty: 0.00041675
Score: 0.987
Data Source: STRINGDB
MMP13
Tchem
Family: Enzyme
Novelty: 0.00057893
Score: 0.986
Data Source: STRINGDB
TNC
Tbio
Novelty: 0.0052441
Score: 0.985
Data Source: Reactome,STRINGDB
TNR
Tbio
Novelty: 0.04804801
Score: 0.982
Data Source: Reactome,STRINGDB
ADAMTS1
Tchem
Family: Enzyme
Novelty: 0.00483758
Score: 0.982
Data Source: STRINGDB
FMOD
Tbio
Novelty: 0.00459438
Score: 0.981
Data Source: STRINGDB
COMP
Tbio
Novelty: 0.00139358
Score: 0.981
Data Source: STRINGDB
MMP1
Tchem
Family: Enzyme
Novelty: 0.00030922
Score: 0.98
Data Source: STRINGDB
Publication Statistics
PubMed Score  2904.41

PubMed score by year
PubTator Score  134.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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