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Tbio
IMMT
MICOS complex subunit MIC60

Protein Summary
Description
Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology (PubMed:22114354, PubMed:25781180).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000410111
  • ENSP00000387262
  • ENSG00000132305
  • ENST00000442664
  • ENSP00000407788
  • ENST00000449247
  • ENSP00000396899

Symbol
  • HMP
  • MIC60
  • MINOS2
  • HMP
  • P87
  • P89
  • PIG4
  • Mic60
  • PIG52
  • MINOS2
  • P87/89
  • MICOS60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
co-expressed gene
0.96
virus perturbation
0.95
kinase perturbation
0.93


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.29   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 331.29   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
inner membrane mitochondrial protein
VGNC:274
470423
Macaque
inner membrane mitochondrial protein
697156
Mouse
MGI:1923864
76614
Rat
RGD:1310684
312444
Dog
inner membrane mitochondrial protein
VGNC:42005
475764
Species
Name
OMA
EggNOG
Inparanoid
Chimp
inner membrane mitochondrial protein
Macaque
inner membrane mitochondrial protein
Mouse
Rat
Dog
inner membrane mitochondrial protein
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q16891-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (3)
Cristae formation (R-HSA-8949613)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cristae formation
Reactome
Mitochondrial biogenesis
Reactome
Organelle biogenesis and maintenance
Name
Explore in Pharos
Explore in Source
Cristae formation
Mitochondrial biogenesis
Organelle biogenesis and maintenance
Gene Ontology Terms (8)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Protein-Protein Interactions (164)
1 – 10 of 164
TRAK1
Tbio
Novelty: 0.03561577
p_int: 0.959763896
p_ni: 0.040236104
Score: 0.17
Data Source: BioPlex,STRINGDB
CD244
Tbio
Novelty: 0.01137579
p_int: 0.952803723
p_ni: 0.047196277
Score: 0.819
Data Source: BioPlex,STRINGDB
MTX2
Tbio
Novelty: 0.02047483
p_int: 0.891858381
p_ni: 0.108141619
Score: 0.997
Data Source: BioPlex,STRINGDB
CLEC5A
Tbio
Novelty: 0.01710591
p_int: 0.762301776
p_ni: 0.237698224
Score: 0.221
Data Source: BioPlex,STRINGDB
SAMM50
Tbio
Novelty: 0.00553631
Score: 0.996
Data Source: STRINGDB
CHCHD3
Tbio
Novelty: 0.05341939
Score: 0.996
Data Source: STRINGDB
CHCHD6
Tbio
Novelty: 0.12379343
Score: 0.993
Data Source: STRINGDB
MINOS1
Tdark
Novelty: 0.40437095
Score: 0.986
Data Source: STRINGDB
APOOL
Tbio
Novelty: 0.08233023
Score: 0.976
Data Source: STRINGDB
DNAJC11
Tbio
Novelty: 0.31080011
Score: 0.969
Data Source: STRINGDB
Publication Statistics
PubMed Score  331.29

PubMed score by year
PubTator Score  242.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer