You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NPPC
C-type natriuretic peptide

Protein Summary
Description
Hormone which plays a role in endochondral ossification through regulation of cartilaginous growth plate chondrocytes proliferation and differentiation. May also be vasoactive and natriuretic. Specifically binds and stimulates the cGMP production of the NPR2 receptor. Binds the clearance receptor NPR3 (By similarity). This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cardiac natriuretic peptides CNP-53, CNP-29 and CNP-22, which belong to the natriuretic family of peptides. The encoded peptides exhibit vasorelaxation activity in laboratory animals and elevated levels of CNP-22 have been observed in the plasma of chronic heart failure patients. [provided by RefSeq, Oct 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295440
  • ENSP00000295440
  • ENSG00000163273
  • ENST00000409852
  • ENSP00000387159

Symbol
  • CNP2
  • CNP
  • CNP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.97
gene perturbation
0.94
histone modification site profile
0.81
cell type or tissue
0.75
biological term
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.74   (req: < 5)
Gene RIFs: 67   (req: <= 3)
Antibodies: 276   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 773.74   (req: >= 5)
Gene RIFs: 67   (req: > 3)
Antibodies: 276   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
3
3
92
balding measurement
1
1
1
13.8
physical activity measurement
2
1
6
3
BMI-adjusted waist circumference
2
1
6
3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
92
balding measurement
1
13.8
physical activity measurement
6
3
BMI-adjusted waist circumference
6
3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide C
VGNC:14324
740147
Macaque
natriuretic peptide C
717026
Mouse
MGI:97369
18159
Rat
RGD:620850
114593
Dog
natriuretic peptide C
VGNC:43927
610169
Species
Name
OMA
EggNOG
Inparanoid
Chimp
natriuretic peptide C
Macaque
natriuretic peptide C
Mouse
Rat
Dog
natriuretic peptide C
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P23582-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (6)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Muscle contraction
Reactome
Physiological factors
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Muscle contraction
Physiological factors
Gene Ontology Terms (29)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (55)
1 – 10 of 55
NPR2
Tbio
Family: Kinase
Novelty: 0.00418989
Score: 0.997
Data Source: Reactome,STRINGDB
NPR3
Tchem
Novelty: 0.00227442
Score: 0.97
Data Source: STRINGDB
NPR1
Tclin
Family: Kinase
Novelty: 0.00170829
Score: 0.948
Data Source: STRINGDB
NPPA
Tchem
Novelty: 0.00046693
Score: 0.804
Data Source: STRINGDB
NPPB
Tbio
Novelty: 0.00024947
Score: 0.788
Data Source: STRINGDB
MME
Tclin
Family: Enzyme
Novelty: 0.00019144
Score: 0.729
Data Source: STRINGDB
GUCY2C
Tclin
Family: Kinase
Novelty: 0.00209733
Score: 0.719
Data Source: STRINGDB
NPTXR
Tbio
Novelty: 0.00727951
Score: 0.683
Data Source: STRINGDB
CNP
Tbio
Family: Enzyme
Novelty: 0.00566142
Score: 0.677
Data Source: STRINGDB
GUCY2F
Tbio
Family: Kinase
Novelty: 0.03634576
Score: 0.673
Data Source: STRINGDB
Publication Statistics
PubMed Score  773.74

PubMed score by year
PubTator Score  362.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: