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Tbio
CHN1
N-chimaerin

Protein Summary
Description
GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance. This gene encodes GTPase-activating protein for ras-related p21-rac and a phorbol ester receptor. It is predominantly expressed in neurons, and plays an important role in neuronal signal-transduction mechanisms. Mutations in this gene are associated with Duane's retraction syndrome 2 (DURS2). Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295497
  • ENSP00000295497
  • ENSG00000128656
  • ENST00000409156
  • ENSP00000386470
  • ENST00000409900
  • ENSP00000386741

Symbol
  • ARHGAP2
  • CHN
  • NC
  • CHN
  • DURS2
  • ARHGAP2
  • RHOGAP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
protein domain
0.85
histone modification site profile
0.84
kinase perturbation
0.76
metabolite
0.71


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.81   (req: < 5)
Gene RIFs: 20   (req: <= 3)
Antibodies: 389   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 69.81   (req: >= 5)
Gene RIFs: 20   (req: > 3)
Antibodies: 389   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chimerin 1
VGNC:134
100611604
Macaque
chimerin 1
698697
Mouse
MGI:1915674
108699
Horse
chimerin 1
VGNC:16510
100065187
Cow
chimerin 1
VGNC:27307
508266
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chimerin 1
Macaque
chimerin 1
Mouse
Horse
chimerin 1
Cow
chimerin 1
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P15882-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (4)
Rho GTPase cycle (R-HSA-194840)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Rho GTPase cycle
Reactome
Signal Transduction
Reactome
Signaling by Rho GTPases
Name
Explore in Pharos
Explore in Source
Rho GTPase cycle
Signal Transduction
Signaling by Rho GTPases
Protein-Protein Interactions (74)
1 – 10 of 74
CHN2
Tbio
Novelty: 0.01065579
p_int: 0.999999998
p_wrong: 1e-9
Score: 0.698
Data Source: BioPlex,STRINGDB
NCK1
Tbio
Novelty: 0.00352084
p_int: 0.999969364
p_ni: 0.000030626
p_wrong: 1.1e-8
Score: 0.169
Data Source: BioPlex,STRINGDB
RAC1
Tbio
Family: Enzyme
Novelty: 0.00365325
Score: 0.971
Data Source: STRINGDB
CDC42
Tchem
Family: Enzyme
Novelty: 0.00032619
Score: 0.96
Data Source: STRINGDB
RAC2
Tbio
Family: Enzyme
Novelty: 0.00116234
Score: 0.951
Data Source: STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.947
Data Source: STRINGDB
CLTB
Tbio
Novelty: 0.00931222
Score: 0.932
Data Source: STRINGDB
RHOA
Tbio
Family: Enzyme
Novelty: 0.00022204
Score: 0.929
Data Source: STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.925
Data Source: STRINGDB
RHOC
Tbio
Family: Enzyme
Novelty: 0.00262213
Score: 0.923
Data Source: STRINGDB
Publication Statistics
PubMed Score  69.81

PubMed score by year
PubTator Score  194.72

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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