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Tbio
FCHSD2
F-BAR and double SH3 domains protein 2

Protein Summary
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311172
  • ENSP00000308978
  • ENSG00000137478
  • ENST00000409418
  • ENSP00000386722
  • ENST00000409853
  • ENSP00000386314

Symbol
  • KIAA0769
  • SH3MD3
  • NWK
  • NWK1
  • SH3MD3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor binding site profile
0.97
virus perturbation
0.85
transcription factor
0.76
histone modification site profile
0.75
cell line
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.47   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 95   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 47.47   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 95   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albumin:globulin ratio measurement
1
1
1
43.5
blood protein measurement
1
1
1
38.8
1
1
0
1.6
7.4
1
1
0
1.5
4.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
albumin:globulin ratio measurement
1
43.5
blood protein measurement
1
38.8
0
1.6
7.4
0
1.5
4.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
FCH and double SH3 domains 2
VGNC:11354
451409
Macaque
FCH and double SH3 domains 2
717996
Mouse
MGI:2448475
207278
Rat
RGD:1304812
308864
Dog
FCH and double SH3 domains 2
VGNC:40807
485204
Species
Name
OMA
EggNOG
Inparanoid
Chimp
FCH and double SH3 domains 2
Macaque
FCH and double SH3 domains 2
Mouse
Rat
Dog
FCH and double SH3 domains 2
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-O94868-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Gene Ontology Terms (4)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (122)
1 – 10 of 122
GOPC
Tbio
Novelty: 0.01110168
p_int: 0.999997467
p_ni: 0.000002495
p_wrong: 3.8e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
ITSN1
Tbio
Novelty: 0.01327346
Score: 0.969
Data Source: STRINGDB
TRIM45
Tbio
Novelty: 0.03874681
Score: 0.891
Data Source: STRINGDB
ITSN2
Tbio
Novelty: 0.03036854
Score: 0.844
Data Source: STRINGDB
STAC
Tbio
Novelty: 0.01982527
Score: 0.84
Data Source: STRINGDB
SPART
Tbio
Novelty: 0.01524727
Score: 0.802
Data Source: STRINGDB
SORBS1
Tbio
Novelty: 0.01480301
Score: 0.796
Data Source: STRINGDB
KIR3DL1
Tbio
Novelty: 0.00308245
Score: 0.733
Data Source: STRINGDB
KIR2DL1
Tbio
Novelty: 0.00523657
Score: 0.701
Data Source: STRINGDB
UBOX5
Tbio
Novelty: 0.37436118
Score: 0.696
Data Source: STRINGDB
Publication Statistics
PubMed Score  47.47

PubMed score by year
PubTator Score  6.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer