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Tbio
CEBPD
CCAAT/enhancer-binding protein delta

Protein Summary
Description
Transcription activator that recognizes two different DNA motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers (PubMed:16397300). Important transcription factor regulating the expression of genes involved in immune and inflammatory responses (PubMed:1741402, PubMed:16397300). Transcriptional activator that enhances IL6 transcription alone and as heterodimer with CEBPB (PubMed:1741402). The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000408965
  • ENSP00000386165
  • ENSG00000221869

Symbol
  • CELF
  • CRP3
  • C/EBP-delta
  • NF-IL6-beta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
1
gene perturbation
0.96
disease perturbation
0.93
PubMedID
0.93
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 849.16   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 240   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 849.16   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 240   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
32.9
eosinophil count
3
1
3
31.7
basophil count
2
1
2
22
monocyte percentage of leukocytes
2
1
2
15.7
neutrophil percentage of leukocytes
2
1
2
11.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
32.9
eosinophil count
3
31.7
basophil count
2
22
monocyte percentage of leukocytes
2
15.7
neutrophil percentage of leukocytes
2
11.6
Pathways (19)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Developmental Biology
Reactome
Immune System
Reactome
Interleukin-4 and Interleukin-13 signaling
Reactome
Signaling by Interleukins
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Developmental Biology
Immune System
Interleukin-4 and Interleukin-13 signaling
Signaling by Interleukins
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (150)
1 – 10 of 150
CEBPB
Tbio
Family: TF
Novelty: 0.00068108
Score: 0.971
Data Source: STRINGDB
STAT3
Tchem
Family: TF
Novelty: 0.00011808
Score: 0.966
Data Source: STRINGDB
PPARG
Tclin
Family: NR
Novelty: 0.00010033
Score: 0.962
Data Source: STRINGDB
CEBPA
Tbio
Family: TF
Novelty: 0.00056459
Score: 0.954
Data Source: STRINGDB
EP300
Tchem
Family: Epigenetic
Novelty: 0.00055009
Score: 0.949
Data Source: STRINGDB
CREBBP
Tchem
Family: Epigenetic
Novelty: 0.00111166
Score: 0.946
Data Source: STRINGDB
KLF5
Tbio
Family: TF
Novelty: 0.00384971
Score: 0.939
Data Source: STRINGDB
NCOA3
Tbio
Family: Epigenetic
Novelty: 0.00193529
Score: 0.938
Data Source: STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.923
Data Source: STRINGDB
PPARGC1A
Tbio
Novelty: 0.0003625
Score: 0.917
Data Source: STRINGDB
Publication Statistics
PubMed Score  849.16

PubMed score by year
PubTator Score  255.65

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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