You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARMC5
Armadillo repeat-containing protein 5

Protein Summary
Description
Involved in fetal development, T-cell function and adrenal gland growth homeostasis (By similarity). Negatively regulates adrenal cells survival. Plays a role in steroidogenesis, modulates steroidogenic enzymes expression and cortisol production (PubMed:24283224, PubMed:28676429). This gene encodes a member of the ARM (armadillo/beta-catenin-like repeat) superfamily. The ARM repeat is a tandemly repeated sequence motif with approximately 40 amino acid long. This repeat is implicated in mediating protein-protein interactions. The encoded protein contains seven ARM repeats. Mutations in this gene are associated with primary bilateral macronodular adrenal hyperplasia, which is also known as ACTH-independent macronodular adrenal hyperplasia 2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268314
  • ENSP00000268314
  • ENSG00000140691
  • ENST00000457010
  • ENSP00000399561
  • ENST00000538189
  • ENSP00000443995
  • ENST00000563544
  • ENSP00000456877

Symbol
  • AIMAH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.81
transcription factor binding site profile
0.8
histone modification site profile
0.72
transcription factor
0.63
protein domain
0.58


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.8   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 79   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 44.8   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 79   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Term: 0
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gestational blood glucose measurement
2
1
0
4.6
43.2
pregnancy
2
1
0
4.6
43.2
Glycosuria
2
1
0
4.6
43.2
parental genotype effect measurement
2
1
0
4.6
43.2
fetal genotype effect measurement
1
1
0
7.8
35.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
gestational blood glucose measurement
0
4.6
43.2
pregnancy
0
4.6
43.2
Glycosuria
0
4.6
43.2
parental genotype effect measurement
0
4.6
43.2
fetal genotype effect measurement
0
7.8
35.2
Gene Ontology Terms (4)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Protein-Protein Interactions (49)
1 – 10 of 49
CUL3
Tbio
Novelty: 0.0028737
p_int: 0.999993174
p_ni: 0.000006819
p_wrong: 7e-9
Score: 0.192
Data Source: BioPlex,STRINGDB
LMO2
Tbio
Novelty: 0.0038279
p_int: 0.999976242
p_ni: 0.000023707
p_wrong: 5.2e-8
Score: 0.181
Data Source: BioPlex,STRINGDB
DXO
Tbio
Family: Enzyme
Novelty: 0.08260087
p_int: 0.999258774
p_ni: 0.00009812
p_wrong: 0.000643106
Score: 0.547
Data Source: BioPlex,STRINGDB
POLR2M
Tbio
Family: Enzyme
Novelty: 0.11413088
p_int: 0.997189123
p_ni: 0.002810877
Data Source: BioPlex
RPAP2
Tbio
Family: Enzyme
Novelty: 0.03383659
p_int: 0.997156709
p_ni: 0.002843027
p_wrong: 2.64e-7
Data Source: BioPlex
ESPL1
Tbio
Family: Enzyme
Novelty: 0.00346666
p_int: 0.974276302
p_ni: 0.025723697
p_wrong: 1e-9
Data Source: BioPlex
AMD1
Tchem
Family: Enzyme
Novelty: 0.00231813
p_int: 0.973611661
p_ni: 0.026388339
Data Source: BioPlex
TBCD
Tbio
Novelty: 0.01161221
p_int: 0.895052462
p_ni: 0.104947538
Data Source: BioPlex
DYNC2H1
Tbio
Novelty: 0.01306616
p_int: 0.866263089
p_ni: 0.133736911
Data Source: BioPlex
GEMIN5
Tbio
Novelty: 0.03683801
p_int: 0.85309325
p_ni: 0.14690675
Data Source: BioPlex
Publication Statistics
PubMed Score  44.80

PubMed score by year
PubTator Score  26.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: