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Tbio
THADA
Thyroid adenoma-associated protein

Protein Classes
Protein Summary
Description
This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000402360
  • ENSP00000385441
  • ENSG00000115970
  • ENST00000404790
  • ENSP00000384266
  • ENST00000405006
  • ENSP00000385995
  • ENST00000405975
  • ENSP00000386088

Symbol
  • GITA
  • KIAA1767
  • GITA
  • ARMC13
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
phenotype
0.94
histone modification site profile
0.91
transcription factor binding site profile
0.91
trait
0.86
transcription factor
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.11   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 100   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 12.11   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 100   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (39)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
9
3
1.1
99.4
testosterone measurement
4
4
4
98.6
4
3
1
1.4
98.2
prostate carcinoma
3
2
0
1.1
91.6
neutrophil count
3
3
3
90.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
1.1
99.4
testosterone measurement
4
98.6
1
1.4
98.2
prostate carcinoma
0
1.1
91.6
neutrophil count
3
90.4
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (3)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
tRNA modification in the nucleus and cytosol
Reactome
tRNA processing
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
tRNA modification in the nucleus and cytosol
tRNA processing
Gene Ontology Terms (7)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
FlyBase
Protein-Protein Interactions (153)
1 – 10 of 153
CYB5B
Tbio
Novelty: 0.09395308
p_int: 0.999899664
p_ni: 0.000100336
Data Source: BioPlex
VSIG2
Tdark
Novelty: 0.32398032
p_int: 0.999834693
p_ni: 0.000165307
Score: 0.182
Data Source: BioPlex,STRINGDB
OPALIN
Tdark
Novelty: 0.08221612
p_int: 0.999825423
p_ni: 0.000174577
Data Source: BioPlex
VASN
Tbio
Novelty: 0.05424159
p_int: 0.999712967
p_ni: 0.000287033
Data Source: BioPlex
TMEM206
Tdark
Novelty: 0.17311172
p_int: 0.999518696
p_ni: 0.000481304
Data Source: BioPlex
TNFRSF1A
Tchem
Novelty: 0.00037847
p_int: 0.998862631
p_ni: 0.001137369
Data Source: BioPlex
CD226
Tbio
Novelty: 0.00374102
p_int: 0.998656645
p_ni: 0.001343355
Data Source: BioPlex
OPRM1
Tclin
Family: GPCR
Novelty: 0.0003701
p_int: 0.99831819
p_ni: 0.00168181
Data Source: BioPlex
C11orf87
Tdark
Novelty: 1.33249342
p_int: 0.991033049
p_ni: 0.008966951
Data Source: BioPlex
CD274
Tclin
Novelty: 0.00013449
p_int: 0.990061959
p_ni: 0.009938041
Data Source: BioPlex
Publication Statistics
PubMed Score  12.11

PubMed score by year
PubTator Score  34.94

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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