You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
NAA60
N-alpha-acetyltransferase 60

Protein Summary
Description
N-alpha-acetyltransferase that specifically mediates the acetylation of N-terminal residues of the transmembrane proteins, with a strong preference for N-termini facing the cytosol (PubMed:25732826). Displays N-terminal acetyltransferase activity towards a range of N-terminal sequences including those starting with Met-Lys, Met-Val, Met-Ala and Met-Met (PubMed:21750686, PubMed:25732826, PubMed:27550639, PubMed:27320834). Required for normal chromosomal segregation during anaphase (PubMed:21750686). May also show histone acetyltransferase activity; such results are however unclear in vivo and would require additional experimental evidences (PubMed:21981917). This gene encodes an enzyme that localizes to the Golgi apparatus, where it transfers an acetyl group to the N-terminus of free proteins. This enzyme acts on histones, and its activity is important for chromatin assembly and chromosome integrity. Alternative splicing and the use of alternative promoters results in multiple transcrip ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360862
  • ENSP00000354108
  • ENSG00000122390
  • ENST00000407558
  • ENSP00000385903
  • ENST00000414063
  • ENSP00000393224
  • ENST00000421765
  • ENSP00000405873
  • ENST00000424546
  • ENSP00000401237
  • ENST00000570819
  • ENSP00000460763
  • ENST00000572169
  • ENSP00000458928
  • ENST00000572584
  • ENSP00000459057
  • ENST00000572942
  • ENSP00000461730
  • ENST00000573580
  • ENSP00000459055
  • ENST00000575076
  • ENSP00000458667
  • ENST00000577013
  • ENSP00000458575
  • ENST00000649205
  • ENSP00000497988
  • ENST00000649360
  • ENSP00000497411

Symbol
  • HAT4
  • NAT15
  • HAT4
  • NatF
  • NAT15
  • hNaa60
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.9
disease perturbation
0.87
transcription factor
0.69
tissue sample
0.68
transcription factor perturbation
0.61


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 138   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 22.22   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 138   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
1
2
46.3
eosinophil percentage of leukocytes
1
1
1
21.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
46.3
eosinophil percentage of leukocytes
1
21.4
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1922013
74763
Rat
RGD:1308915
363545
Dog
N(alpha)-acetyltransferase 60, NatF catalytic subunit
609456
Horse
N(alpha)-acetyltransferase 60, NatF catalytic subunit
VGNC:51169
100065966
Cow
N(alpha)-acetyltransferase 60, NatF catalytic subunit
514154
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
N(alpha)-acetyltransferase 60, NatF catalytic subunit
Horse
N(alpha)-acetyltransferase 60, NatF catalytic subunit
Cow
N(alpha)-acetyltransferase 60, NatF catalytic subunit
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q9H7X0-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (40)
1 – 10 of 40
NAA15
Tbio
Family: Enzyme
Novelty: 0.00513055
Score: 0.92
Data Source: STRINGDB
NAA10
Tbio
Family: Enzyme
Novelty: 0.00086809
Score: 0.901
Data Source: STRINGDB
NAA16
Tbio
Family: Enzyme
Novelty: 0.23261397
Score: 0.883
Data Source: STRINGDB
NAA11
Tbio
Family: Enzyme
Novelty: 0.06535314
Score: 0.878
Data Source: STRINGDB
NAA50
Tbio
Family: Enzyme
Novelty: 0.01843508
Score: 0.876
Data Source: STRINGDB
NAA30
Tbio
Family: Enzyme
Novelty: 0.04701961
Score: 0.872
Data Source: STRINGDB
NAA20
Tbio
Family: Enzyme
Novelty: 0.07814789
Score: 0.844
Data Source: STRINGDB
NAA40
Tbio
Family: Enzyme
Novelty: 0.13882523
Score: 0.832
Data Source: STRINGDB
NAA25
Tbio
Family: Enzyme
Novelty: 0.05422122
Score: 0.794
Data Source: STRINGDB
ZNF597
Tbio
Family: TF
Novelty: 0.04420398
Score: 0.761
Data Source: STRINGDB
Publication Statistics
PubMed Score  22.22

PubMed score by year
PubTator Score  12.19

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer