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Tbio
PRKAR1B
cAMP-dependent protein kinase type I-beta regulatory subunit

Protein Summary
Description
Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. The protein encoded by this gene is a regulatory subunit of cyclic AMP-dependent protein kinase A (PKA), which is involved in the signaling pathway of the second messenger cAMP. Two regulatory and two catalytic subunits form the PKA holoenzyme, disbands after cAMP binding. The holoenzyme is involved in many cellular events, including ion transport, metabolism, and transcription. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000360274
  • ENSP00000353415
  • ENSG00000188191
  • ENST00000403562
  • ENSP00000385349
  • ENST00000406797
  • ENSP00000385749
  • ENST00000537384
  • ENSP00000440449
  • ENST00000544935
  • ENSP00000444487

Symbol
  • PRKAR1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.96
molecular function
0.96
protein domain
0.92
PubMedID
0.77
pathway
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 323   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 14.88   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 323   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
2
3
87
hemoglobin measurement
3
2
3
86.1
red blood cell density measurement
1
1
1
79.6
erythrocyte count
1
1
1
29.9
amino acid measurement
1
1
2
19.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
3
87
hemoglobin measurement
3
86.1
red blood cell density measurement
1
79.6
erythrocyte count
1
29.9
amino acid measurement
2
19.9
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (63)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 34
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Aquaporin-mediated transport
Reactome
CREB1 phosphorylation through the activation of Adenylate Cyclase
Reactome
Ca-dependent events
Reactome
CaM pathway
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Aquaporin-mediated transport
CREB1 phosphorylation through the activation of Adenylate Cyclase
Ca-dependent events
CaM pathway
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (161)
1 – 10 of 161
PRKAR1A
Tbio
Family: Enzyme
Novelty: 0.00311432
p_int: 0.999998904
p_ni: 0.000001086
p_wrong: 1e-8
Score: 0.981
Data Source: BioPlex,Reactome,STRINGDB
GPR161
Tbio
Family: GPCR
Novelty: 0.00235739
p_int: 0.999998324
p_ni: 0.000001676
Score: 0.98
Data Source: BioPlex,STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
p_int: 0.999975872
p_ni: 0.000024121
p_wrong: 7e-9
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
VAPA
Tbio
Novelty: 0.00169209
p_int: 0.999495422
p_ni: 0.000504578
Data Source: BioPlex
NAPG
Tbio
Novelty: 0.02295985
p_int: 0.999145942
p_ni: 0.000854038
p_wrong: 2e-8
Score: 0.437
Data Source: BioPlex,STRINGDB
PRKAR2B
Tbio
Family: Enzyme
Novelty: 0.00456972
p_int: 0.998551639
p_ni: 0.001446855
p_wrong: 0.000001507
Score: 0.937
Data Source: BioPlex,Reactome,STRINGDB
VAPB
Tbio
Novelty: 0.00542377
p_int: 0.997209289
p_ni: 0.002790711
Data Source: BioPlex
GSK3A
Tclin
Family: Kinase
Novelty: 0.00925708
p_int: 0.992218626
p_ni: 0.007781374
Score: 0.185
Data Source: BioPlex,STRINGDB
AKAP7
Tbio
Family: Enzyme
Novelty: 0.04114095
p_int: 0.988460527
p_ni: 0.011539473
Score: 0.285
Data Source: BioPlex,STRINGDB
DUOXA2
Tbio
Family: Enzyme
Novelty: 0.02873436
p_int: 0.982222834
p_ni: 0.017777119
p_wrong: 4.7e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  14.88

PubMed score by year
PubTator Score  6.29

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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