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Tbio
GGT2
Inactive glutathione hydrolase 2

Protein Summary
Description
Isoform 1, isoform 2 and isoform 3 lack catalytic activity due to its inability to undergo the autocatalytic cleavage needed to produce a mature, enzymatically active heterodimer. GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000401924
  • ENSP00000385721
  • ENSG00000133475
  • ENST00000424627
  • ENSP00000402035

Symbol
  • GGT
  • GGT 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease
1
cellular component
0.9
cell line
0.74
pathway
0.57
biological term
0.46


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.25   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 71   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 259.25   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 71   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (8)
Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
PathwayCommons: humancyc
leukotriene biosynthesis
PathwayCommons: humancyc
gamma-glutamyl cycle
Name
Explore in Pharos
Explore in Source
leukotriene biosynthesis
gamma-glutamyl cycle
Gene Ontology Terms (18)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (168)
1 – 10 of 168
GPT
Tbio
Family: Enzyme
Novelty: 0.00003498
Score: 0.894
Data Source: STRINGDB
GAPDH
Tchem
Family: Enzyme
Novelty: 0.00005849
Score: 0.819
Data Source: STRINGDB
ALB
Tchem
Novelty: 0.00000616
Score: 0.806
Data Source: STRINGDB
GGCT
Tchem
Family: Enzyme
Novelty: 0.01154389
Score: 0.751
Data Source: STRINGDB
PLOD3
Tbio
Family: Enzyme
Novelty: 0.02211629
Score: 0.747
Data Source: STRINGDB
LOXL1
Tbio
Family: Enzyme
Novelty: 0.00479897
Score: 0.744
Data Source: STRINGDB
AGA
Tbio
Family: Enzyme
Novelty: 0.01522819
Score: 0.733
Data Source: STRINGDB
HPGDS
Tchem
Family: Enzyme
Novelty: 0.00019629
Score: 0.722
Data Source: STRINGDB
ATF1
Tchem
Family: TF
Novelty: 0.01450941
Score: 0.717
Data Source: STRINGDB
SUGCT
Tbio
Family: Enzyme
Novelty: 0.0075902
Score: 0.71
Data Source: STRINGDB
Publication Statistics
PubMed Score  259.25

PubMed score by year
PubTator Score  24.73

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer