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Tbio
VPREB1
Immunoglobulin iota chain

Protein Summary
Description
Associates with the Ig-mu chain to form a molecular complex that is expressed on the surface of pre-B-cells. This complex presumably regulates Ig gene rearrangements in the early steps of B-cell differentiation. The protein encoded by this gene belongs to the immunoglobulin superfamily and is expressed selectively at the early stages of B cell development, namely, in proB and early preB cells. This gene encodes the iota polypeptide chain that is associated with the Ig-mu chain to form a molecular complex which is expressed on the surface of pre-B cells. The complex is thought to regulate Ig gene rearrangements in the early steps of B-cell differentiation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000403807
  • ENSP00000385361
  • ENSG00000169575

Symbol
  • VPREB
  • IGI
  • IGVPB
  • VPREB
  • CD179a
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.66
disease perturbation
0.62
cell line
0.58
cell type or tissue
0.45
PubMedID
0.45


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.45   (req: < 5)
Gene RIFs: 6   (req: <= 3)
Antibodies: 159   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 123.45   (req: >= 5)
Gene RIFs: 6   (req: > 3)
Antibodies: 159   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
V-set pre-B cell surrogate light chain 1
VGNC:14777
458686
Macaque
immunoglobulin iota chain
698810
Mouse
MGI:98937
22363
Rat
RGD:1588558
303782
Dog
immunoglobulin iota chain-like
486411
Species
Name
OMA
EggNOG
Inparanoid
Chimp
V-set pre-B cell surrogate light chain 1
Macaque
immunoglobulin iota chain
Mouse
Rat
Dog
immunoglobulin iota chain-like
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P12018-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (2)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Hemostasis
Gene Ontology Terms (5)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (51)
1 – 10 of 51
IGLL1
Tbio
Novelty: 0.0032269
Score: 0.998
Data Source: Reactome,STRINGDB
IGHV3-11
Tdark
Novelty: 0.09180836
Score: 0.934
Data Source: STRINGDB
IGLL5
Tbio
Novelty: 0.00459259
Score: 0.798
Data Source: STRINGDB
IGLC1
Tdark
Novelty: 0.00459259
Score: 0.798
Data Source: STRINGDB
PREB
Tbio
Family: TF
Novelty: 0.00595167
Score: 0.716
Data Source: STRINGDB
PSMA6
Tbio
Family: Enzyme
Novelty: 0.01525994
Score: 0.71
Data Source: STRINGDB
IGHV4-38-2
Tdark
Novelty: 0.00021909
Score: 0.698
Data Source: STRINGDB
PAX5
Tbio
Family: TF
Novelty: 0.0012666
Score: 0.676
Data Source: STRINGDB
INS
Tbio
Novelty: 0.00000499
Score: 0.675
Data Source: STRINGDB
EBF1
Tbio
Family: TF
Novelty: 0.00445405
Score: 0.67
Data Source: STRINGDB
Publication Statistics
PubMed Score  123.45

PubMed score by year
PubTator Score  64.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer