Tbio FAM161A Protein FAM161A

Protein Summary

Description

Involved in ciliogenesis. This gene belongs to the FAM161 family. It is expressed mainly in the retina. Mouse studies suggested that this gene is involved in development of retinal progenitors during embryogenesis, and that its activity is restricted to mature photoreceptors after birth. Mutations in this gene cause autosomal recessive retinitis pigmentosa-28. Alternatively spliced transcript variants have been identified.[provided by RefSeq, Jan 2011]

Uniprot Accession IDs

• Q3B820
• B4DJV7
• Q9H8R2

Gene Name

• FAM161A

Ensembl ID

• ENST00000404929
• ENSP00000385158
• ENSG00000170264
• ENST00000405894
• ENSP00000385893

Symbol

• RP28

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
virus perturbation	0.98
histone modification site profile	0.77
cellular component	0.71
transcription factor binding site profile	0.65
microRNA	0.63

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: < 5)

Gene RIFs: 13   (req: <= 3)

Antibodies: 73   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 15.13   (req: >= 5)

Gene RIFs: 13   (req: > 3)

Antibodies: 73   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Gene Ontology Terms (15)

Functions (2)

Components (8)

Processes (5)

Items per page:

10

1 – 2 of 2

GO Term	Evidence	Assigned by
identical protein binding	Inferred from Direct Assay (IDA)	UniProtKB
microtubule binding	Inferred from Mutant Phenotype (IMP)	UniProtKB

Protein-Protein Interactions (104)

Explore Interacting Targets

1 – 10 of 104

• See Interactions on String-DB

LCA5

Tbio

Novelty: 0.05221608

Score: 0.858

Data Source: STRINGDB

CNGA1

Tchem

Family: IC

Novelty: 0.01215127

Score: 0.828

Data Source: STRINGDB

POC1B

Tbio

Novelty: 0.11982426

Score: 0.763

Data Source: STRINGDB

SDCCAG8

Tbio

Novelty: 0.06798507

Score: 0.722

Data Source: STRINGDB

CCDC65

Tdark

Novelty: 0.10161663

Score: 0.698

Data Source: STRINGDB

CERKL

Tbio

Family: Enzyme

Novelty: 0.0547283

Score: 0.683

Data Source: STRINGDB

SPEF2

Tdark

Novelty: 0.0493075

Score: 0.679

Data Source: STRINGDB

POU6F2

Tbio

Family: TF

Novelty: 0.03084244

Score: 0.677

Data Source: STRINGDB

DRC1

Tbio

Novelty: 0.50584913

Score: 0.673

Data Source: STRINGDB

ZNF513

Tbio

Family: TF

Novelty: 1.5

Score: 0.671

Data Source: STRINGDB

Publication Statistics

PubMed Score  15.13

PubMed score by year

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PubTator Score  14.56

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGASADLNTSFSG

1-70

VDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSS

70-140

RSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVED

140-210

YIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKK

210-280

KFRANPVPASVFLPLYHDLVKQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKK

280-350

KTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKC

350-420

KHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPY

420-490

LSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRKSEKERMREYQRELEEREEKLKKRPLLFERVA

490-560

QKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQETKSVTEDKESFNEEEKIEERENGEENY

560-630

FIDTNSQDSYKEKDEANEESEEEKSVEESH

630-660

MATSHRVAKLVASSLQTPVNPITGARVAQYEREDPLKALAAAEAILEDEEEEKVAQPAGASADLNTSFSGVDEHAPISYEDFVNFPDIHHSNEEYFKKVEELKAAHIETMAKLEKMYQDKLHLKEVQPVVIREDSLSDSSRSVSEKNSYHPVSLMTSFSEPDLGQSSSLYVSSSEEELPNLEKEYPRKNRMMTYAKELINNMWTDFCVEDYIRCKDTGFHAAEKRRKKRKEWVPTITVPEPFQMMIREQKKKEESMKSKSDIEMVHKALKKQEEDPEYKKKFRANPVPASVFLPLYHDLVKQKEERRRSLKEKSKEALLASQKPFKFIAREEQKRAAREKQLRDFLKYKKKTNRFKARPIPRSTYGSTTNDKLKEEELYRNLRTQLRAQEHLQNSSPLPCRSACGCRNPRCPEQAVKLKCKHKVRCPTPDFEDLPERYQKHLSEHKSPKLLTVCKPFDLHASPHASIKREKILADIEADEENLKETRWPYLSPRRKSPVRCAGVNPVPCNCNPPVPTVSSRGREQAVRKSEKERMREYQRELEEREEKLKKRPLLFERVAQKNARMAAEKHYSNTLKALGISDEFVSKKGQSGKVLEYFNNQETKSVTEDKESFNEEEKIEERENGEENYFIDTNSQDSYKEKDEANEESEEEKSVEESH

Find similar targets by:

Uniprot Keyword

Alternative splicing
Cell projection
Ciliopathy
Cilium
Cilium biogenesis/degradation
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton
Isopeptide bond