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Tbio
NRXN1
Neurexin-1

Protein Summary
Description
Cell surface protein involved in cell-cell-interactions, exocytosis of secretory granules and regulation of signal transmission. Function is isoform-specific. Alpha-type isoforms have a long N-terminus with six laminin G-like domains and play an important role in synaptic signal transmission. Alpha-type isoforms play a role in the regulation of calcium channel activity and Ca(2+)-triggered neurotransmitter release at synapses and at neuromuscular junctions. They play an important role in Ca(2+)-triggered exocytosis of secretory granules in pituitary gland. They may effect their functions at synapses and in endocrine cells via their interactions with proteins from the exocytotic machinery. Likewise, alpha-type isoforms play a role in regulating the activity of postsynaptic NMDA receptors, a subtype of glutamate-gated ion channels. Both alpha-type and beta-type isoforms may play a role in the formation or maintenance of synaptic junctions via their calcium-dependent interactions (via the ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000404971
  • ENSP00000385142
  • ENSG00000179915
  • ENST00000406316
  • ENSP00000384311
  • ENST00000625672
  • ENSP00000485887

Symbol
  • KIAA0578
  • PTHSL2
  • SCZD17
  • Hs.22998
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.37   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 326.37   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
4
8
16
97.1
self reported educational attainment
4
8
16
97.1
chronotype measurement
3
6
6
1.1
96.7
chronotype measurement
3
6
6
1.1
96.7
body mass index
3
3
6
96.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
16
97.1
self reported educational attainment
16
97.1
chronotype measurement
6
1.1
96.7
chronotype measurement
6
1.1
96.7
body mass index
6
96.6
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1096391
18189
Horse
neurexin 1
VGNC:20895
100052908
Chicken
neurexin 1
CGNC:49297
395398
Zebrafish
ZDB-GENE-070206-1
565531
C. elegans
179503
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Horse
neurexin 1
Chicken
neurexin 1
Zebrafish
C. elegans
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q9ULB1-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (6)
Extracellular matrix organization (R-HSA-1474244)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extracellular matrix organization
Reactome
Neurexins and neuroligins
Reactome
Neuronal System
Reactome
Non-integrin membrane-ECM interactions
Reactome
Protein-protein interactions at synapses
Name
Explore in Pharos
Explore in Source
Extracellular matrix organization
Neurexins and neuroligins
Neuronal System
Non-integrin membrane-ECM interactions
Protein-protein interactions at synapses
Gene Ontology Terms (47)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (277)
1 – 10 of 277
NLGN3
Tbio
Family: Enzyme
Novelty: 0.00819625
Score: 0.998
Data Source: STRINGDB
NLGN1
Tbio
Family: Enzyme
Novelty: 0.0097512
Score: 0.998
Data Source: STRINGDB
NLGN4X
Tbio
Family: Enzyme
Novelty: 0.01004489
Score: 0.997
Data Source: STRINGDB
NLGN2
Tbio
Family: Enzyme
Novelty: 0.01613168
Score: 0.997
Data Source: STRINGDB
CASK
Tchem
Family: Kinase
Novelty: 0.00856437
Score: 0.987
Data Source: STRINGDB
LRRTM2
Tbio
Novelty: 0.08084156
Score: 0.985
Data Source: STRINGDB
LRRTM1
Tbio
Novelty: 0.0409182
Score: 0.983
Data Source: STRINGDB
LRRTM3
Tbio
Novelty: 0.18633527
Score: 0.975
Data Source: STRINGDB
SHANK2
Tbio
Novelty: 0.00710548
Score: 0.975
Data Source: STRINGDB
SYT1
Tbio
Novelty: 0.00176103
Score: 0.974
Data Source: STRINGDB
Publication Statistics
PubMed Score  326.37

PubMed score by year
PubTator Score  113.61

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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