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Tbio
TBC1D10A
TBC1 domain family member 10A

Protein Summary
Description
Acts as GTPase-activating protein for RAB27A, but not for RAB2A, RAB3A, nor RAB4A.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000215790
  • ENSP00000215790
  • ENSG00000099992
  • ENST00000403477
  • ENSP00000384996

Symbol
  • EPI64
  • TBC1D10
  • EPI64
  • TBC1D10
  • dJ130H16.1
  • dJ130H16.2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.62
transcription factor
0.62
transcription factor binding site profile
0.57
tissue sample
0.55
cell line
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.55   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 122   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.55   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 122   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (5)
Membrane Trafficking (R-HSA-199991)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Membrane Trafficking
Reactome
Rab regulation of trafficking
Reactome
TBC/RABGAPs
Reactome
Vesicle-mediated transport
Name
Explore in Pharos
Explore in Source
Membrane Trafficking
Rab regulation of trafficking
TBC/RABGAPs
Vesicle-mediated transport
Gene Ontology Terms (14)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (33)
1 – 10 of 33
FGL1
Tbio
Novelty: 0.04090189
p_int: 1
Score: 0.187
Data Source: BioPlex,STRINGDB
SLC9A3R2
Tbio
Family: Transporter
Novelty: 0.01296563
p_int: 0.999999961
p_ni: 3.9e-8
Score: 0.66
Data Source: BioPlex,STRINGDB
EVA1B
Tdark
Novelty: 3
p_int: 0.999973101
p_ni: 0.000023455
p_wrong: 0.000003443
Score: 0.557
Data Source: BioPlex,STRINGDB
CNOT11
Tbio
Novelty: 0.06871944
p_int: 0.990219413
p_ni: 0.000003132
p_wrong: 0.009777455
Score: 0.243
Data Source: BioPlex,STRINGDB
RAB35
Tbio
Family: Enzyme
Novelty: 0.0201355
Score: 0.986
Data Source: STRINGDB
SYTL1
Tbio
Novelty: 0.12823747
Score: 0.955
Data Source: Reactome,STRINGDB
ARF6
Tbio
Family: Enzyme
Novelty: 0.00305495
Score: 0.949
Data Source: Reactome,STRINGDB
RAB22A
Tbio
Family: Enzyme
Novelty: 0.03160034
Score: 0.746
Data Source: STRINGDB
RAB27A
Tchem
Family: Enzyme
Novelty: 0.00463277
Score: 0.714
Data Source: STRINGDB
SLC9A3R1
Tbio
Family: Transporter
Novelty: 0.0026167
Score: 0.702
Data Source: STRINGDB
Publication Statistics
PubMed Score  6.55

PubMed score by year
PubTator Score  5.4

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGA
1-70
LEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDE
70-140
LDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHM
140-210
PAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFS
210-280
RTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQE
280-350
VVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPG
350-420
SKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSA
420-490
HHRSQESLTSQESEDTYL
490-508
MAKSNGENGPRAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAEGALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKKIRLRCQKGIPPSLRGRAWQYLSGGKVKLQQNPGKFDELDMSPGDPKWLDVIERDLHRQFPFHEMFVSRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLPGYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSVLRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLVQEVVELPVTERQIEREHLIQLRRWQETRGELQCRSPPRLHGAKAILDAEPGPRPALQPSPSIRLPLDAPLPGSKAKPKPPKQAQKEQRKQMKGRGQLEKPPAPNQAMVVAAAGDACPPQHVPPKDSAPKDSAPQDLAPQVSAHHRSQESLTSQESEDTYL