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Tbio
WDR62
WD repeat-containing protein 62

Protein Summary
Description
Required for cerebral cortical development. Plays a role in neuronal proliferation and migration (PubMed:20890278, PubMed:20729831). Plays a role in mother-centriole-dependent centriole duplication; the function seems also to involve CEP152, CDK5RAP2 and CEP63 through a stepwise assembled complex at the centrosome that recruits CDK2 required for centriole duplication (PubMed:26297806). This gene is proposed to play a role in cerebral cortical development. Mutations in this gene have been associated with microencephaly, cortical malformations, and cognitive disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270301
  • ENSP00000270301
  • ENSG00000075702
  • ENST00000401500
  • ENSP00000384792
  • ENST00000587391
  • ENSP00000465525

Symbol
  • C19orf14
  • MCPH2
  • C19orf14
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.96
histone modification site profile
0.84
drug perturbation
0.71
tissue
0.65
small molecule perturbation
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.99   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 51   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 51.99   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 51   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:1923696
233064
Rat
RGD:1306714
308492
Dog
WD repeat domain 62
VGNC:48380
484565
Horse
WD repeat domain 62
VGNC:25009
100060345
Cow
WD repeat domain 62
VGNC:36910
530449
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
WD repeat domain 62
Horse
WD repeat domain 62
Cow
WD repeat domain 62
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-O43379-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Gene Ontology Terms (10)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
HPA
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (114)
1 – 10 of 114
MAPK8
Tchem
Family: Kinase
Novelty: 0.00055723
p_int: 0.99999563
p_ni: 0.00000437
Score: 0.84
Data Source: BioPlex,STRINGDB
AURKA
Tchem
Family: Kinase
Novelty: 0.0010868
p_int: 0.992843709
p_ni: 0.007156291
Score: 0.475
Data Source: BioPlex,STRINGDB
A1BG
Tbio
Novelty: 0.00508743
p_int: 0.98555863
p_ni: 0.01444137
Score: 0.189
Data Source: BioPlex,STRINGDB
KIF2B
Tbio
Novelty: 0.09958244
p_int: 0.98513999
p_ni: 0.01486001
Score: 0.154
Data Source: BioPlex,STRINGDB
DNAJC7
Tbio
Novelty: 0.02133191
p_int: 0.92050049
p_ni: 0.07949951
Data Source: BioPlex
DISC1
Tbio
Novelty: 0.00183442
p_int: 0.893065886
p_ni: 0.106934114
Data Source: BioPlex
ZBBX
Tdark
Novelty: 1.66474399
p_int: 0.875392074
p_ni: 0.124607926
Data Source: BioPlex
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.851152297
p_ni: 0.148847703
Data Source: BioPlex
TENT5A
Tbio
Novelty: 0.08412895
p_int: 0.771498327
p_ni: 0.228501673
Data Source: BioPlex
C6orf141
Tdark
Novelty: 1.46022784
p_int: 0.770956382
p_ni: 0.229043618
Data Source: BioPlex
Publication Statistics
PubMed Score  51.99

PubMed score by year
PubTator Score  35.33

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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