You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
SLC8A1
Sodium/calcium exchanger 1

Protein Summary
Description
Mediates the exchange of one Ca(2+) ion against three to four Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes (PubMed:1374913, PubMed:11241183, PubMed:1476165). Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A1 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Required for normal embryonic heart development and the onset of heart contractions. In cardiac myocytes, Ca(2+) concentrations alternate between high levels during contraction and low levels during relaxation. The increase in Ca(2+) concentration during contraction is primarily due to release of Ca(2+) from intracellular stores. However, some Ca(2+) also en ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000332839
  • ENSP00000332931
  • ENSG00000183023
  • ENST00000402441
  • ENSP00000385188
  • ENST00000403092
  • ENSP00000384763
  • ENST00000405269
  • ENSP00000385535
  • ENST00000405901
  • ENSP00000385678
  • ENST00000406391
  • ENSP00000385811
  • ENST00000406785
  • ENSP00000383886
  • ENST00000408028
  • ENSP00000384908

Symbol
  • CNC
  • NCX1
  • NCX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.95
molecular function
0.91
microRNA
0.84
phenotype
0.78
disease
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.12   (req: < 5)
Gene RIFs: 73   (req: <= 3)
Antibodies: 183   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 432.12   (req: >= 5)
Gene RIFs: 73   (req: > 3)
Antibodies: 183   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 47
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 294
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (294)
1 – 10 of 294
CHEMBL3657664
chemical structure image
CHEMBL3662010
chemical structure image
CHEMBL3662018
chemical structure image
CHEMBL3662023
chemical structure image
CHEMBL3661864
chemical structure image
CHEMBL3662017
chemical structure image
CHEMBL3661976
chemical structure image
CHEMBL3657669
chemical structure image
CHEMBL3661935
chemical structure image
CHEMBL3662005
chemical structure image
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
3
6
96.5
PR interval
2
2
0
2
80.8
bone fracture
1
1
1
75.6
QT interval
2
3
0
1.8
66.9
glomerular filtration rate
2
1
2
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
96.5
PR interval
0
2
80.8
bone fracture
1
75.6
QT interval
0
1.8
66.9
glomerular filtration rate
2
44.2
Pathways (28)
Cardiac conduction (R-HSA-5576891)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 11
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cardiac conduction
Reactome
Hemostasis
Reactome
Ion homeostasis
Reactome
Muscle contraction
Reactome
Platelet calcium homeostasis
Name
Explore in Pharos
Explore in Source
Cardiac conduction
Hemostasis
Ion homeostasis
Muscle contraction
Platelet calcium homeostasis
Gene Ontology Terms (59)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (95)
1 – 10 of 95
PRKACA
Tchem
Family: Kinase
Novelty: 0.03869658
Score: 0.901
Data Source: STRINGDB
PRKACB
Tchem
Family: Kinase
Novelty: 0.01962222
Score: 0.893
Data Source: STRINGDB
PRKG1
Tchem
Family: Kinase
Novelty: 0.0014943
Score: 0.825
Data Source: STRINGDB
SLC8A2
Tbio
Family: Transporter
Novelty: 0.01423879
Score: 0.813
Data Source: STRINGDB
PRKG2
Tchem
Family: Kinase
Novelty: 0.0138455
Score: 0.809
Data Source: STRINGDB
PRKACG
Tbio
Family: Kinase
Novelty: 0.11080061
Score: 0.808
Data Source: STRINGDB
ATP2A2
Tbio
Family: Transporter
Novelty: 0.00133604
Score: 0.806
Data Source: STRINGDB
SLC8A3
Tchem
Family: Transporter
Novelty: 0.01041945
Score: 0.804
Data Source: STRINGDB
ITPR1
Tchem
Family: IC
Novelty: 0.00111834
Score: 0.793
Data Source: STRINGDB
ATP1A2
Tclin
Family: Transporter
Novelty: 0.00606202
Score: 0.774
Data Source: STRINGDB
Publication Statistics
PubMed Score  432.12

PubMed score by year
PubTator Score  583.43

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: