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Tbio
NRG1
Pro-neuregulin-1, membrane-bound isoform

Protein Summary
Description
Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4 (PubMed:10867024, PubMed:7902537). Binds to ERBB3 (PubMed:20682778). Acts as a ligand for integrins and binds (via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its bin ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287842
  • ENSP00000287842
  • ENSG00000157168
  • ENST00000356819
  • ENSP00000349275
  • ENST00000405005
  • ENSP00000384620
  • ENST00000519301
  • ENSP00000429582
  • ENST00000520407
  • ENSP00000434640
  • ENST00000520502
  • ENSP00000433289
  • ENST00000521670
  • ENSP00000428828
  • ENST00000523079
  • ENSP00000430120

Symbol
  • GGF
  • HGL
  • HRGA
  • NDF
  • SMDF
  • GGF
  • HGL
  • HRG
  • NDF
  • ARIA
  • GGF2
  • HRG1
  • HRGA
  • SMDF
  • MST131
  • MSTP131
  • NRG1-IT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
trait
1
biological process
0.99
protein domain
0.97
disease
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1207.89   (req: < 5)
Gene RIFs: 362   (req: <= 3)
Antibodies: 854   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1207.89   (req: >= 5)
Gene RIFs: 362   (req: > 3)
Antibodies: 854   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 69
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (16)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.4
96.2
chronotype measurement
2
2
1
1.1
87.1
Hirschsprung disease
2
2
0
1.9
84.2
hemoglobin measurement
2
2
2
71.4
body mass index
1
1
1
70.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.4
96.2
chronotype measurement
1
1.1
87.1
Hirschsprung disease
0
1.9
84.2
hemoglobin measurement
2
71.4
body mass index
1
70.4
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuregulin 1
VGNC:831
464102
Macaque
neuregulin 1
696275
Mouse
MGI:96083
211323
Rat
RGD:621341
112400
Dog
neuregulin 1
VGNC:43967
482861
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuregulin 1
Macaque
neuregulin 1
Mouse
Rat
Dog
neuregulin 1
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-Q02297-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (60)
Activation of NMDA receptors and postsynaptic events (R-HSA-442755)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NMDA receptors and postsynaptic events
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Name
Explore in Pharos
Explore in Source
Activation of NMDA receptors and postsynaptic events
Constitutive Signaling by Aberrant PI3K in Cancer
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
Gene Ontology Terms (82)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
MGI
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (194)
1 – 10 of 194
RHOBTB3
Tbio
Novelty: 0.09149494
p_int: 0.99907238
p_ni: 0.000927619
p_wrong: 2e-9
Score: 0.17
Data Source: BioPlex,STRINGDB
TMEM39B
Tdark
Novelty: 3.99024108
p_int: 0.99781676
p_ni: 0.002183197
p_wrong: 4.2e-8
Score: 0.19
Data Source: BioPlex,STRINGDB
SFXN3
Tbio
Novelty: 0.18698456
p_int: 0.990861968
p_ni: 0.008096215
p_wrong: 0.001041818
Data Source: BioPlex
SLC25A23
Tbio
Family: Transporter
Novelty: 0.10446757
p_int: 0.989908165
p_ni: 0.009900997
p_wrong: 0.000190839
Score: 0.171
Data Source: BioPlex,STRINGDB
SLC25A16
Tbio
Family: Transporter
Novelty: 0.00778831
p_int: 0.984632669
p_ni: 0.015367331
Score: 0.198
Data Source: BioPlex,STRINGDB
POMT1
Tbio
Family: Enzyme
Novelty: 0.01971429
p_int: 0.98139285
p_ni: 0.01860715
Data Source: BioPlex
TMEM63B
Tdark
Family: IC
Novelty: 0.25017412
p_int: 0.978908085
p_ni: 0.021091885
p_wrong: 3e-8
Data Source: BioPlex
B3GNT2
Tbio
Family: Enzyme
Novelty: 0.02724566
p_int: 0.974691001
p_ni: 0.025308895
p_wrong: 1.05e-7
Data Source: BioPlex
ADGRL1
Tbio
Family: GPCR
Novelty: 0.00957739
p_int: 0.968064349
p_ni: 0.031935574
p_wrong: 7.7e-8
Score: 0.162
Data Source: BioPlex,STRINGDB
HS6ST1
Tbio
Family: Enzyme
Novelty: 0.01352454
p_int: 0.95677649
p_ni: 0.034402501
p_wrong: 0.00882101
Data Source: BioPlex
Publication Statistics
PubMed Score  1207.89

PubMed score by year
PubTator Score  742.67

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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