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Tbio
ADGRV1
Adhesion G-protein coupled receptor V1

Protein Summary
Description
G-protein coupled receptor which has an essential role in the development of hearing and vision. Couples to G-alpha(i)-proteins, GNAI1/2/3, G-alpha(q)-proteins, GNAQ, as well as G-alpha(s)-proteins, GNAS, inhibiting adenylate cyclase (AC) activity and cAMP production. Required for the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells of the inner ear. In response to extracellular calcium, activates kinases PKA and PKC to regulate myelination by inhibiting the ubiquitination of MAG, thus enhancing the stability of this protein in myelin-forming cells of the auditory pathway. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport. Involved in the regulation of bone metabolism. Cleaved ADGRV1 beta-subunit couples with G-alpha(i)-proteins, GNAI1/2/3, and constitutively inhibits adenylate cyclase (AC) activity with a stro ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405460
  • ENSP00000384582
  • ENSG00000164199
  • ENST00000645211
  • ENSP00000495777

Symbol
  • GPR98
  • KIAA0686
  • KIAA1943
  • MASS1
  • VLGR1
  • FEB4
  • GPR98
  • MASS1
  • USH2B
  • USH2C
  • VLGR1
  • VLGR1b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
trait
0.99
protein domain
0.97
cellular component
0.78
gene perturbation
0.74
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.86   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 111   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.86   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 111   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 25
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
2
3
90.6
sex interaction measurement
1
9
9
79.4
1
9
9
79.4
hair color
1
1
0
1.1
67.8
1
1
0
1.3
62.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
3
90.6
sex interaction measurement
9
79.4
9
79.4
hair color
0
1.1
67.8
0
1.3
62.3
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor V1
VGNC:3895
461757
Macaque
adhesion G protein-coupled receptor V1
697794
Mouse
MGI:1274784
110789
Dog
adhesion G protein-coupled receptor V1
VGNC:37654
479153
Opossum
adhesion G protein-coupled receptor V1
100012465
Species
Name
OMA
EggNOG
Inparanoid
Chimp
adhesion G protein-coupled receptor V1
Macaque
adhesion G protein-coupled receptor V1
Mouse
Dog
adhesion G protein-coupled receptor V1
Opossum
adhesion G protein-coupled receptor V1
Protein Structure (0 Structures, 26 AlphaFold Models)
RepresentationColor Scheme

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (10)
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
WikiPathways
GPCRs, Other
WikiPathways
GPCRs, Other
WikiPathways
AMP-activated Protein Kinase (AMPK) Signaling
WikiPathways
ErbB Signaling Pathway
WikiPathways
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Name
Explore in Pharos
Explore in Source
GPCRs, Other
GPCRs, Other
AMP-activated Protein Kinase (AMPK) Signaling
ErbB Signaling Pathway
Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
Gene Ontology Terms (38)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
HGNC
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Protein-Protein Interactions (113)
1 – 10 of 113
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.999600814
p_ni: 0.000399186
Data Source: BioPlex
GPHA2
Tbio
Novelty: 0.01057969
p_int: 0.999438969
p_ni: 0.000561031
Data Source: BioPlex
SCGB1D1
Tbio
Novelty: 0.04199997
p_int: 0.999413919
p_ni: 0.000586081
Data Source: BioPlex
CMA1
Tchem
Family: Enzyme
Novelty: 0.00091144
p_int: 0.999372229
p_ni: 0.000627771
Data Source: BioPlex
PSG8
Tdark
Novelty: 0.1446257
p_int: 0.998981331
p_ni: 0.001018646
p_wrong: 2.3e-8
Data Source: BioPlex
SLAMF1
Tbio
Novelty: 0.00112892
p_int: 0.998277474
p_ni: 0.001722526
Data Source: BioPlex
SCGB1D4
Tdark
Novelty: 0.15597658
p_int: 0.998200258
p_ni: 0.001799742
Data Source: BioPlex
LAG3
Tbio
Novelty: 0.00187736
p_int: 0.997858601
p_ni: 0.002141399
Data Source: BioPlex
NXPH2
Tdark
Novelty: 0.65790631
p_int: 0.997571795
p_ni: 0.002428205
Score: 0.158
Data Source: BioPlex,STRINGDB
PROK2
Tbio
Novelty: 0.00512397
p_int: 0.997476265
p_ni: 0.002523735
Data Source: BioPlex
Publication Statistics
PubMed Score  71.86

PubMed score by year
PubTator Score  128.78

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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