You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
ARNTL
Aryl hydrocarbon receptor nuclear translocator-like protein 1

Protein Summary
Description
Transcriptional activator which forms a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components: the central clock, residing in the suprachiasmatic nucleus (SCN) of the brain, and the peripheral clocks that are present in nearly every tissue and organ system. Both the central and peripheral clocks can be reset by environmental cues, also known as Zeitgebers (German for 'timegivers'). The predominant Zeitgeber for the central clock is light, which is sensed by retina and s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000389707
  • ENSP00000374357
  • ENSG00000133794
  • ENST00000401424
  • ENSP00000385915
  • ENST00000403290
  • ENSP00000384517
  • ENST00000403482
  • ENSP00000385897
  • ENST00000403510
  • ENSP00000385581

Symbol
  • BHLHE5
  • BMAL1
  • MOP3
  • PASD3
  • TIC
  • JAP3
  • MOP3
  • BMAL1
  • PASD3
  • BMAL1c
  • bHLHe5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0.99
molecular function
0.96
kinase perturbation
0.84
virus perturbation
0.79
PubMedID
0.77


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1200.21   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 479   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1200.21   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 479   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 39
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (25)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
2
3
98.1
body mass index
3
3
3
97.5
sex hormone-binding globulin measurement
6
1
6
97.4
triglyceride measurement
6
3
7
93.9
neuroticism measurement
2
3
1
6.3
91.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
C-reactive protein measurement
3
98.1
body mass index
3
97.5
sex hormone-binding globulin measurement
6
97.4
triglyceride measurement
7
93.9
neuroticism measurement
1
6.3
91.6
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (14)
BMAL1:CLOCK,NPAS2 activates circadian gene expression (R-HSA-1368108)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Reactome
Circadian Clock
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
PPARA activates gene expression
Name
Explore in Pharos
Explore in Source
BMAL1:CLOCK,NPAS2 activates circadian gene expression
Circadian Clock
Metabolism
Metabolism of lipids
PPARA activates gene expression
Gene Ontology Terms (45)
Items per page:
10
1 – 10 of 12
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (181)
1 – 10 of 181
CLOCK
Tbio
Family: TF; Epigenetic
Novelty: 0.00159625
p_int: 0.999999503
p_ni: 4.97e-7
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BCAM
Tbio
Novelty: 0.01697541
p_int: 0.999873472
p_ni: 0.000126528
Score: 0.189
Data Source: BioPlex,STRINGDB
ARNTL2
Tbio
Family: TF
Novelty: 0.0039351
p_int: 0.999783265
p_ni: 0.000005115
p_wrong: 0.00021162
Score: 0.821
Data Source: BioPlex,STRINGDB
NPAS2
Tbio
Family: TF
Novelty: 0.00728451
p_int: 0.998849063
p_ni: 5.94e-7
p_wrong: 0.001150342
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
LRFN4
Tbio
Novelty: 0.12511571
p_int: 0.988425392
p_ni: 0.011574608
Score: 0.177
Data Source: BioPlex,STRINGDB
CRY2
Tbio
Novelty: 0.00156961
Score: 0.999
Data Source: Reactome,STRINGDB
CRY1
Tchem
Novelty: 0.00116593
Score: 0.999
Data Source: Reactome,STRINGDB
CSNK1E
Tchem
Family: Kinase
Novelty: 0.00891859
Score: 0.997
Data Source: Reactome,STRINGDB
SIRT1
Tchem
Family: Epigenetic
Novelty: 0.00022265
Score: 0.994
Data Source: STRINGDB
NR1D1
Tchem
Family: NR
Novelty: 0.00250799
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  1200.21

PubMed score by year
PubTator Score  333.99

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: