You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
TFIP11
Tuftelin-interacting protein 11

Protein Summary
Description
Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix. This gene encodes a protein component of the spliceosome that promotes the release of the lariat-intron during late-stage splicing through the recruitment of a pre-mRNA splicing factor called DEAH-box helicase 15. The encoded protein contains a G-patch domain, a hallmark of RNA-processing proteins, that binds DEAH-box helicase 15. This protein contains an atypical nuclear localization sequence as well as a nuclear speckle- ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000405938
  • ENSP00000384297
  • ENSG00000100109
  • ENST00000407148
  • ENSP00000385861
  • ENST00000407431
  • ENSP00000383892
  • ENST00000407690
  • ENSP00000384421
  • ENST00000619735
  • ENSP00000480171

Symbol
  • STIP
  • NTR1
  • STIP
  • TIP39
  • STIP-1
  • Spp382
  • bK445C9.6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.94
kinase perturbation
0.91
hub protein
0.82
cellular component
0.77
drug perturbation
0.71


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.68   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 109   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 57.68   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 109   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (4)
Metabolism of RNA (R-HSA-8953854)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism of RNA
Reactome
Processing of Capped Intron-Containing Pre-mRNA
Reactome
mRNA Splicing
Reactome
mRNA Splicing - Major Pathway
Name
Explore in Pharos
Explore in Source
Metabolism of RNA
Processing of Capped Intron-Containing Pre-mRNA
mRNA Splicing
mRNA Splicing - Major Pathway
Gene Ontology Terms (19)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (230)
1 – 10 of 230
RSRC1
Tbio
Novelty: 0.19164956
p_int: 0.999999666
p_ni: 3.34e-7
Score: 0.842
Data Source: BioPlex,STRINGDB
JMJD6
Tbio
Family: Enzyme
Novelty: 0.00134844
p_int: 0.999998151
p_ni: 0.000001849
Data Source: BioPlex
HDAC11
Tclin
Family: Epigenetic
Novelty: 0.00486766
p_int: 0.999969242
p_ni: 0.000030758
Score: 0.188
Data Source: BioPlex,STRINGDB
SNRPB
Tbio
Novelty: 0.01137048
p_int: 0.999929607
p_ni: 0.000070393
Score: 0.942
Data Source: BioPlex,STRINGDB
SNRPE
Tbio
Novelty: 0.00150118
p_int: 0.999827718
p_ni: 0.000172282
Score: 0.942
Data Source: BioPlex,STRINGDB
SNRNP40
Tbio
Novelty: 0.00203131
p_int: 0.999572155
p_ni: 0.000427845
Score: 0.976
Data Source: BioPlex,STRINGDB
PNKD
Tbio
Family: Enzyme
Novelty: 0.01082297
p_int: 0.999494779
p_ni: 0.000505221
Data Source: BioPlex
SNW1
Tbio
Novelty: 0.01975138
p_int: 0.999169069
p_ni: 0.000830931
Score: 0.955
Data Source: BioPlex,STRINGDB
SNRPN
Tbio
Novelty: 0.00241221
p_int: 0.999011955
p_ni: 0.000988045
Score: 0.944
Data Source: BioPlex,STRINGDB
PRPF19
Tbio
Novelty: 0.01912462
p_int: 0.998976999
p_ni: 0.001023001
Score: 0.986
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  57.68

PubMed score by year
PubTator Score  12.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Sequence
MSLSHLYRDGEGRIDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDDERPSFGGKR
1-70
ARDYSAPVNFISAGLKKGAAEEAELEDSDDEEKPVKQDDFPKDFGPRKLKTGGNFKPSQKGFAGGTKSFM
70-140
DFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSMQDFPVVDS
140-210
EEEAEEEFQKELSQWRKDPSGSKKKPKYSYKTVEELKAKGRISKKLTAPQKELSQVKVIDMTGREQKVYY
210-280
SYSQISHKHNVPDDGLPLQSQQLPQSGKEAKAPGFALPELEHNLQLLIDLTEQEIIQNDRQLQYERDMVV
280-350
NLFHELEKMTEVLDHEERVISNLSKVLEMVEECERRMQPDCSNPLTLDECARIFETLQDKYYEEYRMSDR
350-420
VDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADAFHRLIWEVWMPFVR
420-490
NIVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIHSWIHPWLPLMQ
490-560
ARLEPLYSPIRSKLSSALQKWHPSDSSAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQ
560-630
HMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSV
630-700
KDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQRGIGVAASSVP
700-770
MNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK
770-837
MSLSHLYRDGEGRIDDDDDERENFEITDWDLQNEFNPNRQRHWQTKEEATYGVWAERDSDDERPSFGGKRARDYSAPVNFISAGLKKGAAEEAELEDSDDEEKPVKQDDFPKDFGPRKLKTGGNFKPSQKGFAGGTKSFMDFGSWERHTKGIGQKLLQKMGYVPGRGLGKNAQGIINPIEAKQRKGKGAVGAYGSERTTQSMQDFPVVDSEEEAEEEFQKELSQWRKDPSGSKKKPKYSYKTVEELKAKGRISKKLTAPQKELSQVKVIDMTGREQKVYYSYSQISHKHNVPDDGLPLQSQQLPQSGKEAKAPGFALPELEHNLQLLIDLTEQEIIQNDRQLQYERDMVVNLFHELEKMTEVLDHEERVISNLSKVLEMVEECERRMQPDCSNPLTLDECARIFETLQDKYYEEYRMSDRVDLAVAIVYPLMKEYFKEWDPLKDCTYGTEIISKWKSLLENDQLLSHGGQDLSADAFHRLIWEVWMPFVRNIVTQWQPRNCDPMVDFLDSWVHIIPVWILDNILDQLIFPKLQKEVENWNPLTDTVPIHSWIHPWLPLMQARLEPLYSPIRSKLSSALQKWHPSDSSAKLILQPWKDVFTPGSWEAFMVKNIVPKLGMCLGELVINPHQQHMDAFYWVIDWEGMISVSSLVGLLEKHFFPKWLQVLCSWLSNSPNYEEITKWYLGWKSMFSDQVLAHPSVKDKFNEALDIMNRAVSSNVGAYMQPGARENIAYLTHTERRKDFQYEAMQERREAENMAQRGIGVAASSVPMNFKDLIETKAEEHNIVFMPVIGKRHEGKQLYTFGRIVIYIDRGVVFVQGEKTWVPTSLQSLIDMAK