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Tbio
CHKB
Choline/ethanolamine kinase

Protein Classes
Protein Summary
Description
Has a key role in phospholipid biosynthesis. Catalyzes the first step in phosphatidylethanolamine biosynthesis. Phosphorylates ethanolamine, and can also act on choline (in vitro). Has higher activity with ethanolamine. May not significantly contribute to in vivo phosphatidylcholine biosynthesis. Choline kinase (CK) and ethanolamine kinase (EK) catalyze the phosphorylation of choline/ethanolamine to phosphocholine/phosphoethanolamine. This is the first enzyme in the biosynthesis of phosphatidylcholine/phosphatidylethanolamine in all animal cells. The highly purified CKs from mammalian sources and their recombinant gene products have been shown to have EK activity also, indicating that both activities reside on the same protein. The choline kinase-like protein encoded by CHKL belongs to the choline/ethanolamine kinase family; however, its exact function is not known. Read-through transcripts are expressed from this locus that include exons from the downstream CPT1B locus. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000406938
  • ENSP00000384400
  • ENSG00000100288

Symbol
  • CHETK
  • CHKL
  • CK
  • EK
  • CKB
  • EKB
  • CHKL
  • CHETK
  • CKEKB
  • MDCMC
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.95
molecular function
0.9
histone modification site profile
0.85
cell type or tissue
0.68
disease perturbation
0.68


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.91   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 152   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.91   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 152   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Glycerophospholipid biosynthesis (R-HSA-1483206)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glycerophospholipid biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Reactome
Phospholipid metabolism
Reactome
Synthesis of PC
Name
Explore in Pharos
Explore in Source
Glycerophospholipid biosynthesis
Metabolism
Metabolism of lipids
Phospholipid metabolism
Synthesis of PC
Gene Ontology Terms (6)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (65)
1 – 10 of 65
PCYT2
Tbio
Family: Enzyme
Novelty: 0.04686585
Score: 0.981
Data Source: STRINGDB
PCYT1B
Tbio
Family: Enzyme
Novelty: 0.03486056
Score: 0.972
Data Source: STRINGDB
PCYT1A
Tbio
Family: Enzyme
Novelty: 0.00370919
Score: 0.96
Data Source: STRINGDB
GPCPD1
Tdark
Family: Enzyme
Novelty: 0.01553765
Score: 0.944
Data Source: STRINGDB
CPT1B
Tchem
Family: Enzyme
Novelty: 0.00514892
Score: 0.922
Data Source: STRINGDB
ETNPPL
Tbio
Family: Enzyme
Novelty: 0.27016329
Score: 0.912
Data Source: STRINGDB
CHKA
Tchem
Family: Kinase
Novelty: 0.00334774
Score: 0.903
Data Source: Reactome,STRINGDB
CHAT
Tchem
Family: Enzyme
Novelty: 0.00038631
Score: 0.903
Data Source: STRINGDB
ACHE
Tclin
Family: Enzyme
Novelty: 0.00031476
Score: 0.903
Data Source: STRINGDB
PHOSPHO1
Tchem
Family: Enzyme
Novelty: 0.09057379
Score: 0.843
Data Source: STRINGDB
Publication Statistics
PubMed Score  61.91

PubMed score by year
PubTator Score  32.92

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer