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Tbio
NPY
Pro-neuropeptide Y

Protein Summary
Description
NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. This gene encodes a neuropeptide that is widely expressed in the central nervous system and influences many physiological processes, including cortical excitability, stress response, food intake, circadian rhythms, and cardiovascular function. The neuropeptide functions through G protein-coupled receptors to inhibit adenylyl cyclase, activate mitogen-activated protein kinase (MAPK), regulate intracellular calcium levels, and activate potassium channels. A polymorphism in this gene resulting in a change of leucine 7 to proline in the signal peptide is associated with elevated cholesterol levels, higher alcohol consumption, and may be a risk factor for various metabolic and cardiovascular diseases. The protein also exhibits antimicrobial activity against bacteria and fungi. [provided by RefSeq, Oct 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242152
  • ENSP00000242152
  • ENSG00000122585
  • ENST00000405982
  • ENSP00000385282
  • ENST00000407573
  • ENSP00000384364

Symbol
  • PYY4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
PubMedID
0.86
disease
0.82
disease perturbation
0.79
chemical
0.77


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8622.37   (req: < 5)
Gene RIFs: 213   (req: <= 3)
Antibodies: 554   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 8622.37   (req: >= 5)
Gene RIFs: 213   (req: > 3)
Antibodies: 554   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
1
2
28.3
body height
1
1
1
0.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body mass index
2
28.3
body height
1
0.5
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y
VGNC:4448
744617
Macaque
neuropeptide Y
574114
Mouse
MGI:97374
109648
Rat
RGD:6487865
100912228
Dog
neuropeptide Y
VGNC:43936
475257
Species
Name
OMA
EggNOG
Inparanoid
Chimp
neuropeptide Y
Macaque
neuropeptide Y
Mouse
Rat
Dog
neuropeptide Y
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01303-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (36)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
FOXO-mediated transcription
Reactome
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
FOXO-mediated transcription
FOXO-mediated transcription of oxidative stress, metabolic and neuronal genes
G alpha (i) signalling events
GPCR downstream signalling
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (431)
1 – 10 of 431
NPY1R
Tchem
Family: GPCR
Novelty: 0.00438376
Score: 0.997
Data Source: Reactome,STRINGDB
NPY2R
Tchem
Family: GPCR
Novelty: 0.01177255
Score: 0.995
Data Source: Reactome,STRINGDB
POMC
Tbio
Novelty: 0.00002436
Score: 0.995
Data Source: STRINGDB
SST
Tbio
Novelty: 0.00005944
Score: 0.991
Data Source: STRINGDB
GAL
Tbio
Novelty: 0.0005132
Score: 0.988
Data Source: STRINGDB
NPY5R
Tchem
Family: GPCR
Novelty: 0.01747655
Score: 0.987
Data Source: Reactome,STRINGDB
PMCH
Tbio
Novelty: 0.00600873
Score: 0.979
Data Source: STRINGDB
NPY4R
Tchem
Family: GPCR
Novelty: 0.11465741
Score: 0.976
Data Source: Reactome,STRINGDB
PDYN
Tbio
Novelty: 0.00039564
Score: 0.975
Data Source: STRINGDB
GALR2
Tchem
Family: GPCR
Novelty: 0.00928558
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  8622.37

PubMed score by year
PubTator Score  2100.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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