You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
RELA
Transcription factor p65

Protein Summary
Description
NF-kappa-B is a pleiotropic transcription factor present in almost all cell types and is the endpoint of a series of signal transduction events that are initiated by a vast array of stimuli related to many biological processes such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The heterodimeric RELA-NFKB1 complex appears to be most abundant one. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. The NF-kappa-B heterodimeric RELA-NFKB1 and RELA-REL complexes, for instance, function as transcriptional activators. NF-kappa-B is controlled by various ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000308639
  • ENSP00000311508
  • ENSG00000173039
  • ENST00000406246
  • ENSP00000384273

Symbol
  • NFKB3
  • p65
  • CMCU
  • NFKB3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
hub protein
1
kinase
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1460.41   (req: < 5)
Gene RIFs: 861   (req: <= 3)
Antibodies: 3431   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1460.41   (req: >= 5)
Gene RIFs: 861   (req: > 3)
Antibodies: 3431   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 101
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
bortezomib
chemical structure image
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
1
1
16.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
1
16.4
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RELA proto-oncogene, NF-kB subunit
VGNC:10283
466665
Macaque
RELA proto-oncogene, NF-kB subunit
715919
Mouse
MGI:103290
19697
Rat
RGD:727889
309165
Dog
RELA proto-oncogene, NF-kB subunit
VGNC:45466
483729
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RELA proto-oncogene, NF-kB subunit
Macaque
RELA proto-oncogene, NF-kB subunit
Mouse
Rat
Dog
RELA proto-oncogene, NF-kB subunit
Protein Data Bank (10)
1 – 5 of 10
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (239)
Activation of NF-kappaB in B cells (R-HSA-1169091)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 70
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of NF-kappaB in B cells
Reactome
Adaptive Immune System
Reactome
C-type lectin receptors (CLRs)
Reactome
CD209 (DC-SIGN) signaling
Reactome
CLEC7A (Dectin-1) signaling
Name
Explore in Pharos
Explore in Source
Activation of NF-kappaB in B cells
Adaptive Immune System
C-type lectin receptors (CLRs)
CD209 (DC-SIGN) signaling
CLEC7A (Dectin-1) signaling
Gene Ontology Terms (109)
Items per page:
10
1 – 10 of 29
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Protein-Protein Interactions (588)
1 – 10 of 588
NFKBIA
Tchem
Novelty: 0.00022873
p_int: 0.999999997
p_ni: 3e-9
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
NFKBIB
Tbio
Novelty: 0.00517222
p_int: 0.999999997
p_ni: 3e-9
Score: 0.996
Data Source: BioPlex,Reactome,STRINGDB
REL
Tbio
Family: TF
Novelty: 0.00038265
p_int: 0.999999755
p_ni: 2.45e-7
p_wrong: 1e-9
Score: 0.988
Data Source: BioPlex,STRINGDB
RELB
Tbio
Family: TF
Novelty: 0.00216805
p_int: 0.999999545
p_ni: 4.55e-7
Score: 0.974
Data Source: BioPlex,Reactome,STRINGDB
C2orf27A
Tdark
Novelty: 2.91059359
p_int: 0.999707622
p_ni: 0.000292375
p_wrong: 2e-9
Data Source: BioPlex
FBXW11
Tbio
Novelty: 0.0715377
p_int: 0.99920131
p_ni: 0.00079869
Score: 0.916
Data Source: BioPlex,Reactome,STRINGDB
BTRC
Tbio
Novelty: 0.00293475
p_int: 0.997572044
p_ni: 0.002427956
Score: 0.948
Data Source: BioPlex,Reactome,STRINGDB
NUFIP2
Tbio
Novelty: 0.09366649
p_int: 0.948716992
p_ni: 0.051172321
p_wrong: 0.000110687
Score: 0.226
Data Source: BioPlex,STRINGDB
LINC01587
Tdark
Novelty: 0.48128342
p_int: 0.940429022
p_ni: 0.059570971
p_wrong: 7e-9
Score: 0.181
Data Source: BioPlex,STRINGDB
DAPP1
Tbio
Novelty: 0.05145215
p_int: 0.905464869
p_ni: 0.089771172
p_wrong: 0.004763959
Data Source: BioPlex
Publication Statistics
PubMed Score  1460.41

PubMed score by year
PubTator Score  2856.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: