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Tbio
POMC
Pro-opiomelanocortin

Protein Summary
Description
Corticotropin: Stimulates the adrenal glands to release cortisol. Melanocyte-stimulating hormone alpha: Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes. Melanocyte-stimulating hormone beta: Increases the pigmentation of skin by increasing melanin production in melanocytes. Beta-endorphin: Endogenous orexigenic opiate. Met-enkephalin: Endogenous opiate. This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroid ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000264708
  • ENSP00000264708
  • ENSG00000115138
  • ENST00000380794
  • ENSP00000370171
  • ENST00000395826
  • ENSP00000379170
  • ENST00000405623
  • ENSP00000384092

Symbol
  • LPH
  • MSH
  • NPP
  • POC
  • ACTH
  • CLIP
  • OBAIRH
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
disease
0.75
biological process
0.74
cellular component
0.7
biological term
0.63


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41913.34   (req: < 5)
Gene RIFs: 178   (req: <= 3)
Antibodies: 2232   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41913.34   (req: >= 5)
Gene RIFs: 178   (req: > 3)
Antibodies: 2232   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 24
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
1
0
1.1
6.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
6.4
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
proopiomelanocortin
VGNC:336
459074
Macaque
proopiomelanocortin
694430
Mouse
MGI:97742
18976
Rat
RGD:3366
24664
Dog
proopiomelanocortin
VGNC:44808
403659
Species
Name
OMA
EggNOG
Inparanoid
Chimp
proopiomelanocortin
Macaque
proopiomelanocortin
Mouse
Rat
Dog
proopiomelanocortin
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P01189-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (66)
Androgen biosynthesis (R-HSA-193048)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 36
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Androgen biosynthesis
Reactome
Biological oxidations
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
Cytochrome P450 - arranged by substrate type
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Androgen biosynthesis
Biological oxidations
Class A/1 (Rhodopsin-like receptors)
Cytochrome P450 - arranged by substrate type
Cytokine Signaling in Immune system
Gene Ontology Terms (30)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Mutant Phenotype (IMP)
UniProtKB
Protein-Protein Interactions (570)
1 – 10 of 570
TSPAN11
Tdark
Novelty: 0.37247094
p_int: 0.999999849
p_ni: 1.45e-7
p_wrong: 6e-9
Score: 0.187
Data Source: BioPlex,STRINGDB
TTL
Tchem
Family: Enzyme
Novelty: 0.03494724
p_int: 0.999999571
p_ni: 3.95e-7
p_wrong: 3.4e-8
Score: 0.309
Data Source: BioPlex,STRINGDB
E2F4
Tbio
Family: TF
Novelty: 0.00317412
p_int: 0.999997002
p_ni: 0.000002953
p_wrong: 4.5e-8
Score: 0.451
Data Source: BioPlex,STRINGDB
UBR4
Tbio
Family: Enzyme
Novelty: 0.03924839
p_int: 0.944304582
p_ni: 0.055695418
Score: 0.183
Data Source: BioPlex,STRINGDB
KLHL15
Tbio
Novelty: 0.54712519
p_int: 0.928369608
p_ni: 0.071630392
Score: 0.183
Data Source: BioPlex,STRINGDB
AMD1
Tchem
Family: Enzyme
Novelty: 0.00231813
p_int: 0.875258509
p_ni: 0.124741491
Score: 0.212
Data Source: BioPlex,STRINGDB
CRH
Tbio
Novelty: 0.000147
Score: 0.997
Data Source: STRINGDB
MC2R
Tclin
Family: GPCR
Novelty: 0.00485539
Score: 0.997
Data Source: Reactome,STRINGDB
MC4R
Tclin
Family: GPCR
Novelty: 0.00091593
Score: 0.996
Data Source: Reactome,STRINGDB
NPY
Tbio
Novelty: 0.00012637
Score: 0.995
Data Source: STRINGDB
Publication Statistics
PubMed Score  41913.34

PubMed score by year
PubTator Score  12246.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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