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Tbio
MATN3
Matrilin-3

Protein Classes
Protein Summary
Description
Major component of the extracellular matrix of cartilage and may play a role in the formation of extracellular filamentous networks. This gene encodes a member of von Willebrand factor A domain containing protein family. This family of proteins is thought to be involved in the formation of filamentous networks in the extracellular matrices of various tissues. This protein contains two von Willebrand factor A domains; it is present in the cartilage extracellular matrix and has a role in the development and homeostasis of cartilage and bone. Mutations in this gene result in multiple epiphyseal dysplasia. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000407540
  • ENSP00000383894
  • ENSG00000132031
  • ENST00000421259
  • ENSP00000398753

Symbol
  • HOA
  • OS2
  • EDM5
  • DIPOA
  • OADIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.81
protein domain
0.73
PubMedID
0.73
transcription factor perturbation
0.61
tissue sample
0.59


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.61   (req: < 5)
Gene RIFs: 31   (req: <= 3)
Antibodies: 206   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 241.61   (req: >= 5)
Gene RIFs: 31   (req: > 3)
Antibodies: 206   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (6)
ECM proteoglycans (R-HSA-3000178)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Reactome
Metabolism of proteins
Reactome
Post-translational protein modification
Reactome
Post-translational protein phosphorylation
Name
Explore in Pharos
Explore in Source
ECM proteoglycans
Extracellular matrix organization
Metabolism of proteins
Post-translational protein modification
Post-translational protein phosphorylation
Protein-Protein Interactions (161)
1 – 10 of 161
TF
Tbio
Novelty: 0.00231826
p_int: 0.977789847
p_ni: 0.022210153
Score: 0.922
Data Source: BioPlex,STRINGDB
PBLD
Tbio
Novelty: 0.09777309
p_int: 0.920409261
p_ni: 0.079590739
Score: 0.455
Data Source: BioPlex,STRINGDB
GDA
Tbio
Family: Enzyme
Novelty: 0.01846276
p_int: 0.820741467
p_ni: 0.179258533
Score: 0.379
Data Source: BioPlex,STRINGDB
COMP
Tbio
Novelty: 0.00139358
Score: 0.983
Data Source: STRINGDB
FN1
Tchem
Novelty: 0.00003647
Score: 0.942
Data Source: STRINGDB
PDIA6
Tchem
Family: Enzyme
Novelty: 0.01692178
Score: 0.932
Data Source: STRINGDB
APOB
Tchem
Novelty: 0.00008247
Score: 0.932
Data Source: STRINGDB
VWA1
Tbio
Novelty: 0.00212445
Score: 0.923
Data Source: STRINGDB
HSP90B1
Tchem
Novelty: 0.00135881
Score: 0.923
Data Source: STRINGDB
BMP4
Tchem
Novelty: 0.00047387
Score: 0.916
Data Source: STRINGDB
Publication Statistics
PubMed Score  241.61

PubMed score by year
PubTator Score  98.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer