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Tbio
IFITM3
Interferon-induced transmembrane protein 3

Protein Summary
Description
IFN-induced antiviral protein which disrupts intracellular cholesterol homeostasis. Inhibits the entry of viruses to the host cell cytoplasm by preventing viral fusion with cholesterol depleted endosomes. May inactivate new enveloped viruses which buds out of the infected cell, by letting them go out with a cholesterol depleted membrane. Active against multiple viruses, including influenza A virus, SARS coronavirus (SARS-CoV), Marburg virus (MARV) and Ebola virus (EBOV), Dengue virus (DNV), West Nile virus (WNV), human immunodeficiency virus type 1 (HIV-1) and vesicular stomatitis virus (VSV). Can inhibit: influenza virus hemagglutinin protein-mediated viral entry, MARV and EBOV GP1,2-mediated viral entry, SARS-CoV S protein-mediated viral entry and VSV G protein-mediated viral entry. Plays a critical role in the structural stability and function of vacuolar ATPase (v-ATPase). Establishes physical contact with the v-ATPase of endosomes which is critical for proper clathrin localization ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000399808
  • ENSP00000382707
  • ENSG00000142089

Symbol
  • 1-8U
  • IP15
  • DSPA2b
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
virus perturbation
1
disease perturbation
0.97
PubMedID
0.94
cellular component
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.6   (req: < 5)
Gene RIFs: 72   (req: <= 3)
Antibodies: 307   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 232.6   (req: >= 5)
Gene RIFs: 72   (req: > 3)
Antibodies: 307   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
2
2
87.1
eosinophil percentage of leukocytes
2
2
2
70.9
eosinophil percentage of granulocytes
1
1
1
34.9
neutrophil percentage of granulocytes
1
1
1
28.2
1
1
0
1.1
22.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
2
87.1
eosinophil percentage of leukocytes
2
70.9
eosinophil percentage of granulocytes
1
34.9
neutrophil percentage of granulocytes
1
28.2
0
1.1
22.7
Orthologs (6)
1 – 5 of 6
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon induced transmembrane protein 3
VGNC:1065
738726
Macaque
interferon-induced transmembrane protein 3
696527
Mouse
MGI:1933382
80876
Rat
RGD:1595844
361673
Dog
interferon-induced transmembrane protein 1-like
475935
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon induced transmembrane protein 3
Macaque
interferon-induced transmembrane protein 3
Mouse
Rat
Dog
interferon-induced transmembrane protein 1-like
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-Q01628-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (4)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Immune System
Reactome
Interferon Signaling
Reactome
Interferon alpha/beta signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Immune System
Interferon Signaling
Interferon alpha/beta signaling
Gene Ontology Terms (15)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Inferred from Electronic Annotation (IEA)
UniProtKB-SubCell
Protein-Protein Interactions (148)
1 – 10 of 148
IFITM2
Tbio
Novelty: 0.02496648
Score: 0.988
Data Source: STRINGDB
MX1
Tbio
Novelty: 0.00072554
Score: 0.975
Data Source: STRINGDB
ISG15
Tbio
Novelty: 0.00203781
Score: 0.973
Data Source: STRINGDB
IFITM1
Tbio
Novelty: 0.00441449
Score: 0.973
Data Source: STRINGDB
RSAD2
Tbio
Novelty: 0.0056473
Score: 0.972
Data Source: STRINGDB
IFI35
Tbio
Novelty: 0.04309126
Score: 0.967
Data Source: STRINGDB
IFIT3
Tbio
Novelty: 0.00568113
Score: 0.966
Data Source: STRINGDB
IRF7
Tbio
Family: TF
Novelty: 0.0021839
Score: 0.964
Data Source: STRINGDB
IFIT1
Tbio
Novelty: 0.00562299
Score: 0.963
Data Source: STRINGDB
IFI6
Tbio
Novelty: 0.02590679
Score: 0.962
Data Source: STRINGDB
Publication Statistics
PubMed Score  232.60

PubMed score by year
PubTator Score  95.64

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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